Background: Cancer affects the emotional well-being of patients and caregivers, highlighting the need for effective communication strategies. This study explores a community-based communication intervention for Latino caregiver–patient dyads coping with cancer. The acceptability of the intervention, along with its associated facilitators and barriers, are crucial considerations. Methods: Three focus group interviews involved healthcare providers, community partners, patients, and caregivers to discuss the communication needs of this population and the components of a communication intervention while identifying facilitators and barriers to the intervention. Qualitative thematic content analysis was conducted using Nvivo v12, ensuring reliability through independent analysis and consensus building. Results: Participants (89% female, average age of 53) included patients (30%), caregivers (30%), community partners (25%), and healthcare providers (15%), and they discussed the overall acceptability of adapting a communication intervention, where they emphasized benefits for caregivers and patients, primarily through support groups. Communication strategies accepted by participants include psychological support, cancer education, assertive communication skills, and methods for improved interactions with healthcare providers and extended family. Conclusions: Participants’ responses align with the current literature, emphasizing problem-solving, mutual support, and communication strategies and underscoring the role of community partners. The study underlines the necessity for culturally tailored communication interventions for Latino families facing cancer.

(1) Background: Coping with a cancer diagnosis can be a challenging process, in which patients and caregivers often require family support. For an adequate support network, there must be clear communication among patients, caregivers, and family members. However, the literature has not adequately discussed communication interventions with extended family members. Our research team identified the need to incorporate communication strategies among patients, caregivers, and extended family. For this reason, we aimed to develop a communication module for patients with cancer, caregivers, and extended family members. (2) Methods: We conducted two steps to address the study’s objective: (a) a narrative literature review to identify communication strategies or interventions and (b) a data triangulation with the narrative literature review findings, the primary study findings, and the cultural expert expertise. (3) Results: The module content included learning what to say and improving general communication. Within the content were communication strategies such as prompt lists, priority lists, methods of telling others, delegating, seeking support, and others. (4) Conclusions: Enhancing the communication among patients with cancer, caregivers, and extended family promotes adequate family support. Nevertheless, future studies should explore the acceptability and implementation strategies of protocols focused on communication.