Hector Garcia Martin

Dr. Hector Garcia Martin

orcid

Research Focus & Metrics

Academic Career Length

25Years (2002-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 November 2007 in Nature
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Journal Article
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FWFalk Warnecke
Falk Warnecke
PLPeter Luginbühl
Peter Luginbühl
NINatalia Ivanova
Natalia Ivanova
MGMajid Ghassemian
Majid Ghassemian
TRToby H. Richardson
Toby H. Richardson
JLJared R. Leadbetter
Jared R. Leadbetter

24 September 2006 in Nature Biotechnology
Verified
Journal Article
Closed access
PDF file
HMHector Garcia Martin
Hector Garcia Martin
NINatalia Ivanova
Natalia Ivanova
VKVictor Kunin
Victor Kunin
FWFalk Warnecke
Falk Warnecke
KBKerrie Barry
Kerrie Barry
PHPhilip Hugenholtz
Philip Hugenholtz

23 September 2019 in Nature Reviews Microbiology
Verified
Journal Article
Closed access
PDF file
CLChristopher E. Lawson
Christopher E. Lawson
WHWilliam R. Harcombe
William R. Harcombe
RHRoland Hatzenpichler
Roland Hatzenpichler
SLStephen R. Lindemann
Stephen R. Lindemann
FLFrank E. Löffler
Frank E. Löffler
KMKatherine D. McMahon
Katherine D. McMahon

17 July 2007 in Proceedings of the National Academy of Sciences
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Journal Article
Closed access
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YMYann Marcy
Yann Marcy
COCleber Ouverney
Cleber Ouverney
EBElisabeth Bik
Elisabeth Bik
TLTina Lösekann
Tina Lösekann
NINatalia Ivanova
Natalia Ivanova
SQStephen Quake
Stephen Quake
We have developed a microfluidic device that allows the isolation and genome amplification of individual microbial cells, thereby enabling organism-level genomic analysis of complex microbial ecosystems without the need for culture. This device was used to perform a directed survey of the human subgingival crevice and to isolate bacteria having rod-like morphology. Several isolated microbes had a 16S rRNA sequence that placed them in candidate phylum TM7, which has no cultivated or sequenced members. Genome amplification from individual TM7 cells allowed us to sequence and assemble >1,000 genes, providing insight into the physiology of members of this phylum. This approach enables single-cell genetic analysis of any uncultivated minority member of a microbial community.

10 December 2006 in Nature Methods
Verified
Journal Article
Closed access
AMAlice Carolyn McHardy
Alice Carolyn McHardy
HMHector Garcia Martin
Hector Garcia Martin
ATAristotelis Tsirigos
Aristotelis Tsirigos
PHPhilip Hugenholtz
Philip Hugenholtz
Isidore RigoutsosIsidore Rigoutsos
Isidore Rigoutsos

1 January 2021 in Metabolic Engineering
Verified
Journal Article
Open access
CLChristopher E. Lawson
Christopher E. Lawson
JMJose Manuel Martí
Jose Manuel Martí
TRTijana Radivojevic
Tijana Radivojevic
SJSai Vamshi R. Jonnalagadda
Sai Vamshi R. Jonnalagadda
RGReinhard Gentz
Reinhard Gentz
HMHector Garcia Martin
Hector Garcia Martin
Machine learning provides researchers a unique opportunity to make metabolic engineering more predictable. In this review, we offer an introduction to this discipline in terms that are relatable to metabolic engineers, as well as providing in-depth illustrative examples leveraging omics data and improving production. We also include practical advice for the practitioner in terms of data management, algorithm libraries, computational resources, and important non-technical issues. A variety of applications ranging from pathway construction and optimization, to genetic editing optimization, cell factory testing, and production scale-up are discussed. Moreover, the promising relationship between machine learning and mechanistic models is thoroughly reviewed. Finally, the future perspectives and most promising directions for this combination of disciplines are examined.