Emerging science continues to establish the detrimental effects of malnutrition in acute neurological diseases such as traumatic brain injury, stroke, status epilepticus and anoxic brain injury. The primary pathological pathways responsible for secondary brain injury include neuroinflammation, catabolism, immune suppression and metabolic failure, and these are exacerbated by malnutrition. Given this, there is growing interest in novel nutritional interventions to promote neurological recovery after acute brain injury. In this review, we will describe how malnutrition impacts the biomolecular mechanisms of secondary brain injury in acute neurological disorders, and how nutritional status can be optimized in both pediatric and adult populations. We will further highlight emerging therapeutic approaches, including specialized diets that aim to resolve neuroinflammation, immunodeficiency and metabolic crisis, by providing pre-clinical and clinical evidence that their use promotes neurologic recovery. Using nutrition as a targeted treatment is appealing for several reasons that will be discussed. Given the high mortality and both short- and long-term morbidity associated with acute brain injuries, novel translational and clinical approaches are needed.
29 September 2023 in Nutrition in Clinical Practice
Nutrition impact symptoms and unintended weight loss are prevalent in patients with gastrointestinal cancers, especially during the perioperative period or while prescribed anticancer treatments. Because patients may experience loss of lean body mass and malnutrition, aggressive nutrition intervention prior to surgery should be considered. Cancer prehabilitation is a process spanning the care continuum from diagnosis to the time of surgery encompassing nutrition support, psychological and physical assessment, and targeted interventions. Thirteen studies published between 2013 and 2023 were included in this review and evaluated prehabilitation programs’ impact on postoperative outcomes in patients with gastrointestinal cancers. Literature continues to emerge supporting the integration of nutrition into a prehabilitation program because of its potential to contribute to improved clinical outcomes, quality of life, and cost‐effectiveness, but considerable variation exists with respect to the specific recommendations provided by current prehabilitation programs.
Introduction: Patterns of dietary intake are known risk factors for both kidney stone formation and recurrence. 1,2 Dietary recommendations such as the Dietary Approaches To Stop Hypertension (DASH) diet can reduce risk, 3,4 but patients may lack knowledge or a practical understanding on implementing these diet patterns. Virtual teaching kitchens have proven effective in improving dietary practices in other populations, but have not been applied to patients with kidney stones. 5,6 This study assessed the effectiveness of virtual teaching kitchen sessions in enhancing dietary confidence and practices for kidney stone prevention. Methods: Eligible adults, aged 18 years and older, with a history of recurrent kidney stones were recruited to participate in one of two virtual teaching kitchen sessions. Pre-intervention surveys were administered to participants assessing individual cooking habits and dietary confidence. Post-intervention surveys assessed changes in cooking attitudes, dietary confidence, and program satisfaction. Results: Forty-six participants completed both pre- and post-intervention surveys. Results showed significant improvements in enjoyment of trying new recipes, reduced frustration with cooking, and perceptions of home-cooked meals as both affordable and healthy. Participants also reported finding cooking less tiring and increased confidence in adopting key dietary practices, including reducing added sugar intake, choosing lean proteins, using spices instead of salt, consuming more fruits and vegetables, and controlling portion sizes (all p<0.05). Conclusions: The virtual teaching kitchen intervention significantly improved participants’ confidence and attitudes toward adopting dietary practices essential for kidney stone prevention, highlighting its promise as an educational tool for patients.
17 September 2026 in Journal of the Academy of Nutrition and Dietetics