The objective of this study was to evaluate the usefulness of the serum biomarkers myeloperoxidase (MPO), paraoxonase (PON), and plasma asprosin in acute myocardial infarction (AMI) diagnosis and assess their compatibility with routinely screened cardiac biomarkers. This study was conducted using a prospective cross-sectional design and included 90 patients, consisting of 60 patients diagnosed with AMI (30 with ST-segment elevation and 30 with non-ST-segment elevation on ECG) and 30 controls (without a diagnosis of AMI). Changes in the levels of cardiac biomarkers (Hs-cTnI, CK, CK-MB), lipid profile (TC, TG, LDL, HDL), MPO, PON, asprosin, and routine biochemical parameters of patients were evaluated. Furthermore, receiver operating characteristic curve analysis revealed the diagnostic value of Hs-cTnI, MPO, PON, and asprosin in predicting AMI. Binary logistic regression analysis of cardiac marker concentrations was used to predict the presence of AMI. In contrast, multinomial logistic regression analysis was conducted to predict the type of AMI and the control group. The median levels of MPO and plasma asprosin were found to be higher in the patient group (3.22 [interquartile range {IQR}: 2.4–4.4] ng/ml and 10.84 [IQR: 8.8–17.8] ng/ml, respectively) than in the control group (2.49 [IQR: 1.9–2.9] ng/ml and 4.82 [IQR: 4.6–8.0] ng/ml, respectively) (p = 0.001 and p < 0.001, respectively). The median levels of PON were 8.94 (IQR: 7.6–10.4) ng/ml in the patient group and 10.44 (IQR: 9.1–20.0) ng/ml in the control group (p < 0.001). In the binary logistic regression model, compared with the control group, a 1 ng/ml increase in MPO level increased the odds of having AMI by 3.61 (p = 0.041, 95% CI: 1.055–12.397), whereas a 1 ng/ml increase in asprosin level increased the odds of having AMI by 2.33 (p < 0.001, 95% CI: 1.479–3.683). In the multinominal logistic regression model, compared with the control group, a 1 ng/ml increase in the MPO level increased the odds of having NSTEMI by 4.14 (p = 0.025, 95% CI: 1.195–14.350), whereas a 1 ng/ml increase in asprosin concentrations increased the odds of having NSTEMI by 2.35 (p < 0.001, 95% CI: 1.494–3.721). Herein, MPO and asprosin concentrations increased with Hs-cTnI, and a decrease in PON concentration indicated that oxidant–antioxidant parameters and adipokines were related to AMI pathogenesis.

Objectives: The purpose of this retrospective study was to investigate the relationship between 25 OH vitamin D (25[OH]D) deficiency and iron-deficient anaemia (IDA) in the pediatric population. This was aimed to provide a better insight to IDA follow-up and treatment. Methods: The data of 120 patients diagnosed with IDA and 125 healthy pediatric patients were analyzed retrospectively. Serum vitamin B ₁₂ , Folate and 25(OH)D levels, between IDA and healthy groups were evaluated. The relationship between vitamins levels and IDA parameters were examined. Logistic regression analysis was used to assess whether 25(OH)D deficiency levels were an independent risk factor for diagnosing IDA. Results: In the comparison of vitamins levels between groups, only mean serum 25(OH)D levels were found to be statistically significantly (p=0.000) lower (13.00 ± 2.50 ng/mL) in the group with IDA compared to the healthy group (25.98 ± 3.66 ng/mL). There were strong positive correlations between 25(OH)D deficiency levels and IDA. The deficiency of 25(OH)D levels was not found to be an independent risk factor for IDA (ORs: 0.958, 95%CI: 0.917–1.000). Conclusions: Although current results confirm the association between 25(0H)D deficiency and IDA in pediatric patients, they indicate that there was no independent risk factor for IDA.

Objective: The aim of this study was to investigate the effect of Thalidomide and Etanercept on inflammation parameters in a neonatal rat sepsis model induced with Lipopolysaccharide (LPS). Materials and methods: Four-week-old male Wistar Albino rats were used in the experiment. LPS (5 mg/kg) was administered to rats as sepsis-inducing agent and two anti-inflammatory drugs, Thalidomide and Etanercept were given intraperitoneally as chemotherapeutic agents. The septic neonatal rats were treated with Thalidomide (0.5 mg/kg), Etanercept (1 mg/kg), and a combination of the two. All therapeutic agents were injected half an hour after injecting LPS. It took 24 h to perform the entire experiment. Whereupon, liver tissues of the animals were removed, presepsin of liver tissue and NF-κB levels were measured by ELISA analysis and NF-κB protein expression levels were determined by Western blotting. Results: A significant increase was detected in presepsin and NF-κB levels in LPS group compared to sham and treatment groups. In Western Blot evaluations, there was a significant decrease in the expression of NF-κB protein in treatment groups compared to sepsis group. Conclusions: It was observed that Thalidomide and Etanercept had potential effects on the treatment of neonatal sepsis.

Aim: The aim of this study is to evaluate the relationship between infection-induced PV and inflammatory parameters levels, WBC, NLR, PLR and CRP in elderly patients. Material and Method: In our study, 122 patients with peripheral vertigo complaints were retrospectively evaluated. Their gender, age, the type of admission, emergency room discharge and hospitalization, hospital admission time, complaints, and physical examination findings rates were examined. Results: The mean age was 73.4 years.. 115 patients (94.3%) were discharged after follow-up in the emergency department, while 7 patients (5.7%) were hospitalized. Complaints were 75.4% dizziness, 18% nausea-vomiting and 6.4% headache, respectively. There was no statistically significant difference in PLT, NEU, LYM, NEU / LYM and PLT / LYM values. Conclusion: In our study, WBC and CRP were significantly higher in patients. The results of our study showed that it can be used actively in the diagnosis of inflammatory causes in the pathogenesis of elderly patients with peripheral vertigo.