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This paper reports a multiscale analysis method to predict the thermo-mechanical coupling performance of composite structures with quasi-periodic properties. In these material structures, the configurations are periodic and the material coefficients are quasi-periodic, i.e., they depend not only on the microscale information but also on the macro location. Also, a mutual interaction between displacement and temperature fields is considered in the problem, which is our particular interest in this study. The multiscale asymptotic expansions of the temperature and displacement fields are constructed and associated error estimation in nearly pointwise sense is presented. Then, a finite element-difference algorithm based on the multiscale analysis method is brought forward in detail. Finally, some numerical examples are given. And the numerical results show that the multiscale method presented in this paper is effective and reliable to study the nonlinear thermo-mechanical coupling problem of composite structures with quasi-periodic properties.