Background/Objectives: Diabetic foot ulcers (DFUs) are a common and serious complication of diabetes, often leading to infection, amputation, and reduced quality of life. Platelet-rich plasma (PRP) therapy has emerged as a promising treatment due to its potential to accelerate wound healing through growth factors and cytokines. Despite growing interest, evidence on PRP’s efficacy and safety in DFU management remains variable. This article critically reviews recent studies to evaluate the effectiveness of PRP in promoting ulcer healing, while examining methodological rigor, ethical considerations, and research parameters to provide a comprehensive, evidence-based assessment for clinical application. Materials and Methods: This review explores the biological mechanisms underlying platelet-rich plasma (PRP) as an adjunctive therapy for DFUs, focusing on its regenerative capabilities. PRP is an autologous concentration of platelets containing growth factors and bioactive molecules that promote angiogenesis, cellular proliferation, and extracellular matrix remodeling. Various application methods—topical, injectable, gel-based, and PRP-enhanced dressings—are examined. The review also evaluates the efficacy of PRP as monotherapy and in combination with other interventions such as debridement and split-thickness skin grafting. Results: Clinical studies suggest that PRP, particularly when used alongside surgical debridement or skin grafting, significantly enhances healing outcomes in patients with non-healing DFUs. It provides a biologically favorable environment for tissue regeneration while reducing inflammation and potentially exhibiting antimicrobial properties. However, variability in PRP preparation techniques, application protocols, and patient selection criteria presents challenges to standardization and broader clinical adoption. Conclusions: While PRP therapy demonstrates significant potential in the management of diabetic foot ulcers, further randomized controlled trials with standardized methodologies are essential to establish optimal treatment protocols and confirm long-term benefits. PRP offers a minimally invasive, autologous, and biologically active treatment modality that may serve as a vital component in the multidisciplinary approach to DFU management.

Introduction: Wound healing in burn patients presents a substantial clinical challenge. Various topical agents are available for the treatment of burn wounds. Facial burns present an increased challenge due to the complex management required, which impacts both physical recovery and psychological well-being. Aim: This study aimed to assess the efficacy of some natural products in treating facial burns. Materials and methods: The study included 50 patients grouped by age, sex, burn etiology, severity, and duration of treatment over a three-year period. Using an open approach technique, these patients received twice-daily applications of natural products such as oils, creams, and ointments. Gentle massage was used during application to ensure complete penetration of the products into the affected areas. Results: Effective penetration of the oils and ointments into the eschar tissue was observed, facilitating rapid eschar separation and improved aesthetic results. Patients reported complete recovery within 10 days with favorable esthetic results. This protocol demonstrated successful management of superficial facial wounds. Conclusions: Natural products proved effective in treating challenging wounds, including burns, edema, and post-surgical conditions, yielding positive outcomes.

Introduction: Expansion of tissues is a physiological phenomenon observed in processes such as pregnancy, breast growth, tumor development, and formation of seromas or hematomas. Over the last decade, there has been an increase in the number of patients with post-burn and post-traumatic defects and contractures. After Neumann introduced it in 1957, surgical treatment with tissue expanders has become an established method for managing major defects that do not have enough surrounding tissue to form a flap. This technique allows tissue defects to be covered with tissue that has similar color, thickness, and elasticity to the surrounding area. When combined with other plastic surgery methods, tissue expansion facilitates the coverage of large soft tissue defects of various etiologies with minimal formation of new scars and minimal donor site morbidity. Aim: Our study aimed to demonstrate the role of tissue expansion in reconstructive surgery, particularly in the treatment of soft tissue injuries in the scalp. Materials and methods: In this study we present ten cases treated for tissue defects using the expander technique. We used expanders of various shapes and sizes, with volumes ranging from 400 to 500 ml. Results: Reconstruction was deemed successful in 9 out of 10 patients. In one patient with scalp carcinoma, treatment was not completed due to rapidly progressing multiple metastatic lesions in parenchymal organs. The study observed particularly good results in six patients, good results in two patients, and satisfactory results in one patient. The total duration of treatment ranged from 1.5 to 2.5 months. Conclusion: Tissue expansion is an extremely suitable method for repairing the effects of thermal, mechanical, or combined injuries.

Introduction: burns are the fourth most common trauma. Regardless of the percentage, all burns require specialised treatment. Burns over 20% of total body surface area/ТBSA/ in adults and over 10% in children are called extensive. They require fluid resuscitation and surgical treatment. It is believed that tissue destruction, combined with capillary dysfunction and a pronounced inflammatory response, lead to the development of hypovolemia and thermal shock. The goal: to validate a protocol for the treatment of extensive burns, including first aid, fluid resuscitation treatment, surgical interventions, rehabilitation, and care for the consequences of burns. Material and methods: we tracked and compared the extensive burns of two random years, demographics, treatment types and outcome of it. Discussion: treatment of thermal shock includes proper initial assessment, timely infusion therapy, early surgical treatment and wound covering, rehabilitation and active surveillance. For the outcome of the treatment, the general condition of the patient, the type and depth of the burn, as well as the time of starting the surgical treatment are important. These factors determine the outcome of the treatment, the development of cicatricial tissue and the preservation of the physiological capacity of motion. Conclusion: extensive burns are a challenge for both plastic surgeons and anesthesiologists. The therapeutic approach follows a certain algorithm depending on many factors.