Glioma is a kind of brain disease with high incidence, high recurrence rate, high mortality, and low cure rate. To obtain accurate diagnosis results of brain glioma, doctors need to manually compare the imaging results of different modalities many times, which will increase the diagnosis time and reduce the diagnostic efficiency. Image fusion technology has been widely used in recent years to obtain information on multimodal medical images. This paper proposes a novel image fusion framework, target information enhanced image fusion network (TIEF), using cross-modal learning and information enhancement techniques. The framework consists of a multi-sequence feature extraction block, a feature selection block, and a fusion block. The multi-sequence feature extraction block consists of multiple sobel dense conv leaky ReLu block (SDCL-block). SDCL-block mainly realizes the extraction of edge features, shallow features, and deep features. The feature selection block identifies the feature channels with rich texture information and strong discrimination ability through the effective combination of global information entropy criterion and feature jump connection. The feature fusion block mainly comprises multi-head and spatial attention mechanisms, which can realize the fusion of intra-modality and inter-modality features. On this basis, considering the influence of tumor spatial location and structure information on the fusion results, a loss function is designed, which is a weighted combination of texture loss, structure loss, and saliency loss so that texture information from multimodal magnetic resonance imaging (MMRI) and saliency information from different anatomical structures of the brain can be fused at the same time to improve the expression ability of features. In this paper, the TIEF algorithm is trained and validated on the MMRI and (Single-Photon Emission Computed Tomography-MRI) SPECT-MRI datasets of glioma and generalized on the (Computed Tomography-MRI) CT-MRI dataset of meningioma to verify the performance of the TIEF algorithm. In the image fusion task, quantitative results showed that TIEF exhibited optimal or suboptimal performance in information entropy, spatial frequency, and average gradient metrics. Qualitative results indicate that the fused images can highlight tumor and edematous features. A downstream image segmentation task was used for evaluation to further verify TIEF’s effectiveness. TIEF achieved the best results in both (Dice similarity coefficient) Dice and (Hausdorff distance 95%) HD95 segmentation metrics. In the generalization task, quantitative results indicated that TIEF obtained more information in the meningioma dataset. In conclusion, TIEF can effectively achieve cross-domain information acquisition and fusion and has robustness and generalization ability.

Epilepsy, as a serious neurological disorder, can be detected by analyzing the brain signals produced by neurons. Electroencephalogram (EEG) signals are the most important data source for monitoring these brain signals. However, these complex, noisy, nonlinear and nonstationary signals make detecting seizures become a challenging task. Feature-based seizure detection algorithms have become a dominant approach for automatic seizure detection. This study presents an algorithm for automatic seizure detection based on novel features with clinical and statistical significance. Our algorithms achieved the best results on two benchmark datasets, outperforming traditional feature-based methods and state-of-the-art deep learning algorithms. Accuracy exceeded 99.99% on both benchmark public datasets, with the 100% correct detection of all seizures on the second one. Due to the interpretability and robustness of our algorithm, combined with its minimal computational resource requirements and time consumption, it exhibited substantial potential value in the realm of clinical application. The coefficients of variation of datasets proposed by us makes the algorithm data-specific and can give theoretical guidance on the selection of appropriate random spectral features for different datasets. This will broaden the applicability scenario of our feature-based approach.

With the advent of the data era, medical image data plays an increasingly important role in diagnosing and treating diseases. This study combined deep learning, ensemble learning, and mathematical theory to construct a Stacking algorithm model based on the Naive Bayes method to achieve more accurate classification of medical images. In the Stacking algorithm, the results of the primary classifier are treated equally, and the performance of the primary classifier is ignored. The poor performance of the primary classifier will affect the final classification result. To solve this problem, a Stacking algorithm based on the Naive Bayes method is proposed in this paper. Firstly, the performance of the primary classifier is evaluated, and the output of the primary classifier is selected reasonably through the evaluation results. Secondly, the VGGNet, InceptionNet, and ResNet convolutional networks were used as primary classifiers to construct a complete Stacking algorithm based on the Naive Bayes method. Next, the algorithm was tested and validated using COVID-19 and NoCOVID-19 lung CT image data. Finally, it is compared with a single primary classifier and the traditional Stacking algorithm. The experimental results show that the Stacking algorithm based on the Naive Bayes method is suitable for the binary classification task of medical images and has better classification results than a single primary classifier and the traditional Stacking algorithm.