Ladislav Mirossay

Ladislav Mirossay

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Academic Career Length

39Years (1988-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 April 2008 in Pharmacological Research
Verified
Journal Article
Closed access
JMJan Mojzis
Jan Mojzis
LVL Varinska
L Varinska
GMG Mojzisova
G Mojzisova
Irena KostovaIrena Kostova
Irena Kostova
LMLadislav Mirossay
Ladislav Mirossay
22 May 2015 in International Journal of Molecular Sciences
Verified
Journal Article
Open access
PDF file
LVLenka Varinská
Lenka Varinská
Peter GalPeter Gal
Peter Gal
GMGabriela Mojzisova
Gabriela Mojzisova
LMLadislav Mirossay
Ladislav Mirossay
JMJan Mojzis
Jan Mojzis
Epidemiological studies have revealed that high consumption of soy products is associated with low incidences of hormone-dependent cancers, including breast and prostate cancer. Soybeans contain large amounts of isoflavones, such as the genistein and daidzain. Previously, it has been demonstrated that genistein, one of the predominant soy isoflavones, can inhibit several steps involved in carcinogenesis. It is suggested that genistein possesses pleiotropic molecular mechanisms of action including inhibition of tyrosine kinases, DNA topoisomerase II, 5α-reductase, galectin-induced G2/M arrest, protein histidine kinase, and cyclin-dependent kinases, modulation of different signaling pathways associated with the growth of cancer cells (e.g., NF-κB, Akt, MAPK), etc. Moreover, genistein is also a potent inhibitor of angiogenesis. Uncontrolled angiogenesis is considered as a key step in cancer growth, invasion, and metastasis. Genistein was found to inhibit angiogenesis through regulation of multiple pathways, such as regulation of VEGF, MMPs, EGFR expressions and NF-κB, PI3-K/Akt, ERK1/2 signaling pathways, thereby causing strong antiangiogenic effects. This review focuses on the antiangiogenic properties of soy isoflavonoids and examines their possible underlying mechanisms.
22 December 2017 in International Journal of Molecular Sciences
Verified
Journal Article
Open access
PDF file
LMLadislav Mirossay
Ladislav Mirossay
LVLenka Varinská
Lenka Varinská
JMJan Mojzis
Jan Mojzis
Chalcones are precursors of flavonoid biosynthesis in plants. Both flavonoids and chalcones are intensively investigated because of a large spectrum of their biological activities. Among others, anticancer and antiangiogenic effects account for the research interest of these substances. Because of an essential role in cancer growth and metastasis, angiogenesis is considered to be a promising target for cancer treatment. Currently used antiangiogenic agents are either synthetic compounds or monoclonal antibodies. However, there are some limitations of their use including toxicity and high price, making the search for new antiangiogenic compounds very attractive. Nowadays it is well known that several natural compounds may modulate basic steps in angiogenesis. A lot of studies, also from our lab, showed that phytochemicals, including polyphenols, are potent modulators of angiogenesis. This review paper is focused on the antiangiogenic effect of flavonoids and chalcones and discusses possible underlying cellular and molecular mechanisms.
31 May 2021 in Cancers
Verified
Journal Article
Open access
PDF file
RMRadka Michalková
Radka Michalková
LMLadislav Mirossay
Ladislav Mirossay
MGMaria Gazdova
Maria Gazdova
Martin KelloMartin Kello
Martin Kello
JMJan Mojzis
Jan Mojzis
Although great progress has been made in the treatment of cancer, the search for new promising molecules with antitumor activity is still one of the greatest challenges in the fight against cancer due to the increasing number of new cases each year. Chalcones (1,3-diphenyl-2-propen-1-one), the precursors of flavonoid synthesis in higher plants, possess a wide spectrum of biological activities including antimicrobial, anti-inflammatory, antioxidant, and anticancer. A plethora of molecular mechanisms of action have been documented, including induction of apoptosis, autophagy, or other types of cell death, cell cycle changes, and modulation of several signaling pathways associated with cell survival or death. In addition, blockade of several steps of angiogenesis and proteasome inhibition has also been documented. This review summarizes the basic molecular mechanisms related to the antiproliferative effects of chalcones, focusing on research articles from the years January 2015–February 2021.
15 September 2009 in The Pharmacogenomics Journal
Verified
Journal Article
Closed access
MČMARTINA ČIŽMÁRIKOVÁ
MARTINA ČIŽMÁRIKOVÁ
MWM Wagnerova
M Wagnerova
LSL Schonova
L Schonova
VHV Habalova
V Habalova
AKA Kohut
A Kohut
AMA Mirossay
A Mirossay
15 November 2023 in Biomolecules
Verified
Journal Article
Open access
PDF file
MČMARTINA ČIŽMÁRIKOVÁ
MARTINA ČIŽMÁRIKOVÁ
RMRadka Michalková
Radka Michalková
LMLadislav Mirossay
Ladislav Mirossay
GMGabriela Mojžišová
Gabriela Mojžišová
MZMartina Zigova
Martina Zigova
JMJan Mojzis
Jan Mojzis
Cancer is a complex and multifaceted disease with a high global incidence and mortality rate. Although cancer therapy has evolved significantly over the years, numerous challenges persist on the path to effectively combating this multifaceted disease. Natural compounds derived from plants, fungi, or marine organisms have garnered considerable attention as potential therapeutic agents in the field of cancer research. Ellagic acid (EA), a natural polyphenolic compound found in various fruits and nuts, has emerged as a potential cancer prevention and treatment agent. This review summarizes the experimental evidence supporting the role of EA in targeting key hallmarks of cancer, including proliferation, angiogenesis, apoptosis evasion, immune evasion, inflammation, genomic instability, and more. We discuss the molecular mechanisms by which EA modulates signaling pathways and molecular targets involved in these cancer hallmarks, based on in vitro and in vivo studies. The multifaceted actions of EA make it a promising candidate for cancer prevention and therapy. Understanding its impact on cancer biology can pave the way for developing novel strategies to combat this complex disease.