Certain small noncoding microRNAs (miRNAs) are differentially expressed in normal tissues and cancers, which makes them great candidates for biomarkers for cancer. Previously, a selected subset of miRNAs has been experimentally verified to be linked to breast cancer. In this paper, we validated the importance of these miRNAs using a machine learning approach on miRNA expression data. We performed feature selection, using Information Gain (IG), Chi-Squared (CHI2) and Least Absolute Shrinkage and Selection Operation (LASSO), on the set of these relevant miRNAs to rank them by importance. We then performed cancer classification using these miRNAs as features using Random Forest (RF) and Support Vector Machine (SVM) classifiers. Our results demonstrated that the miRNAs ranked higher by our analysis had higher classifier performance. Performance becomes lower as the rank of the miRNA decreases, confirming that these miRNAs had different degrees of importance as biomarkers. Furthermore, we discovered that using a minimum of three miRNAs as biomarkers for breast cancers can be as effective as using the entire set of 1800 miRNAs. This work suggests that machine learning is a useful tool for functional studies of miRNAs for cancer detection and diagnosis.

In this paper, the effectiveness of deep learning for automatic classification of grouper species by their vocalizations has been investigated. In the proposed approach, wavelet denoising is used to reduce ambient ocean noise, and a deep neural network is then used to classify sounds generated by different species of groupers. Experimental results for four species of groupers show that the proposed approach achieves a classification accuracy of around 90% or above in all of the tested cases, a result that is significantly better than the one obtained by a previously reported method for automatic classification of grouper calls.

Grouper, a family of marine fishes, produce distinct vocalizations associated with their reproductive behavior during spawning aggregation. These low frequencies sounds (50–350 Hz) consist of a series of pulses repeated at a variable rate. In this paper, an approach is presented for automatic classification of grouper vocalizations from ambient sounds recorded in situ with fixed hydrophones based on weighted features and sparse classifier. Group sounds were labeled initially by humans for training and testing various feature extraction and classification methods. In the feature extraction phase, four types of features were used to extract features of sounds produced by groupers. Once the sound features were extracted, three types of representative classifiers were applied to categorize the species that produced these sounds. Experimental results showed that the overall percentage of identification using the best combination of the selected feature extractor weighted mel frequency cepstral coefficients and sparse classifier achieved 82.7% accuracy. The proposed algorithm has been implemented in an autonomous platform (wave glider) for real-time detection and classification of group vocalizations.

Kidney cancer is one of the deadliest diseases and its diagnosis and subtype classification are crucial for patients’ survival. Thus, developing automated tools that can accurately determine kidney cancer subtypes is an urgent challenge. It has been confirmed by researchers in the biomedical field that miRNA dysregulation can cause cancer. In this paper, we propose a machine learning approach for the classification of kidney cancer subtypes using miRNA genome data. Through empirical studies we found 35 miRNAs that possess distinct key features that aid in kidney cancer subtype diagnosis. In the proposed method, Neighbourhood Component Analysis (NCA) is employed to extract discriminative features from miRNAs and Long Short Term Memory (LSTM), a type of Recurrent Neural Network, is adopted to classify a given miRNA sample into kidney cancer subtypes. In the literature, only a couple of kidney subtypes have been considered for classification. In the experimental study, we used the miRNA quantitative read counts data, which was provided by The Cancer Genome Atlas data repository (TCGA). The NCA procedure selected 35 of the most discriminative miRNAs. With this subset of miRNAs, the LSTM algorithm was able to group kidney cancer miRNAs into five subtypes with average accuracy around 95% and Matthews Correlation Coefficient value around 0.92 under 10 runs of randomly grouped 5-fold cross-validation, which were very close to the average performance of using all miRNAs for classification.

Intracranial Hemorrhage (ICH) has high rates of mortality, and risk factors associated with it are sometimes nearly impossible to avoid. Previous techniques to detect ICH using machine learning have shown some promise. However, due to a limited number of labeled medical images available, which often causes poor model accuracy in terms of the Dice coefficient, there is much to be improved. In this paper, we propose a modified u-net and curriculum learning strategy using a multi-task semi-supervised attention-based model, initially introduced by Chen et al., to segment ICH sub-groups from CT images. Using a modified inverse-sigmoid-based curriculum learning training strategy, we were able to stabilize Chen’s algorithm experimentally. This semi-supervised model produced higher Dice coefficient values in comparison to a supervised counterpart, regardless of the amount of labeled data used to train the model. Specifically, when training with 80% of the ground truth data, our semi-supervised model produced a Dice coefficient of 0.67, which was higher than 0.61, obtained by a comparable supervised model. This result also surpassed by a greater margin the one obtained by using the out-of-the-box u-net by Hssayeni et al.

Communication barriers pose significant challenges for the Deaf and Hard-of-Hearing (DHH) community, limiting their access to essential services, social interactions, and professional opportunities. To bridge this gap, assistive technologies leveraging artificial intelligence (AI) and deep learning have gained prominence. This study presents a real-time American Sign Language (ASL) interpretation system that integrates deep learning with keypoint tracking to enhance accessibility and foster inclusivity. By combining the YOLOv11 model for gesture recognition with MediaPipe for precise hand tracking, the system achieves high accuracy in identifying ASL alphabet letters in real time. The proposed approach addresses challenges such as gesture ambiguity, environmental variations, and computational efficiency. Additionally, this system enables users to spell out names and locations, further improving its practical applications. Experimental results demonstrate that the model attains a mean Average Precision (mAP@0.5) of 98.2%, with an inference speed optimized for real-world deployment. This research underscores the critical role of AI-driven assistive technologies in empowering the DHH community by enabling seamless communication and interaction.