Mirko Domenico Castiglione

Dr. Mirko Domenico Castiglione

orcid

Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 March 2024 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
SGSerena Maria Chiara Giardina
Serena Maria Chiara Giardina
GTGianluca Testa
Gianluca Testa
ECEnrica Rosalia Cuffaro
Enrica Rosalia Cuffaro
MCMirko Domenico Castiglione
Mirko Domenico Castiglione
Marco SapienzaMarco Sapienza
Marco Sapienza
Vito PavoneVito Pavone
Vito Pavone
Background: Olecranon fractures are common injuries of the upper limb in adults. Simple displaced trasverse fractures are generally surgically treated with tension-band wiring (TBW) or plate fixation (PF). The purpose of this retrospective study is to compare the clinical-functional outcome, complications and reoperation rates between TBW and PF for Mayo IIA fractures. Methods: 72 patients treated with PF or TBW at our institution, completed our survey and clinical evaluation and their demographic and clinical data were recorded and analysed. The clinical-functional outcomes were evaluated assessing ROMs and three validated scoring systems: the Disabilities of the Arm, Shoulder, and Hand (DASH), the Mayo Elbow Performance Score (MEPS) and the Patient American Shoulder and Elbow Surgeons Standardized Elbow Assessment score (pASES-e). Results: 38 patients (53%) underwent TBW and 34 (47%) PF. The mean DASH, MEPS and pASES-e scores were respectively 14.5 ± 17.2, 80.5 ± 14.7 and 83.6 ± 12.4 in the TBW group and 21 ± 21.7, 75.6 ± 15.3 and 75.1 ± 19.2 in the PF group (p = 0.16, p = 0.17 and p = 0.03). The mean duration of surgery and hospitalisation period were longer in the PF group (p = 0.002, p = 0.37) whereas the complication and reoperation rates were higher after TBW (p = 0.15, p = 0.24). Conclusions: According to the literature, both TBW and PF resulted comparable valid surgical options for the treatment of simple isolated displaced olecranon fractures. Our results corroborate previous findings, showing good/excellent outcomes without significant differences.

1 February 2025 in Cancers
Verified
Journal Article
Open access
PDF file
DCDavide Giuseppe Castiglione
Davide Giuseppe Castiglione
APAnnamaria Porreca
Annamaria Porreca
DFDaniele Falsaperla
Daniele Falsaperla
FLFederica Libra
Federica Libra
EDEmanuele David
Emanuele David
MGMassimo Galia
Massimo Galia
Objectives: This study aimed to assess the performance of the LI-RADS tumor response algorithm in analyzing inter-reader agreement in patients with hepatocellular carcinoma (HCC) treated with Microwave Ablation (MWA) and Transarterial Embolization (TAE) and the relationship between inter-reader agreement and Neutrophils to Lymphocytes ratio dynamic variations at different time points to explore how inflammation influences tumor response and its interpretation on imaging. Methods: A retrospective analysis was conducted on 78 HCC patients treated with MWA or TAE. Two independent radiologists evaluated pre- and post-treatment imaging and assigned categories according to the LR-TRA. Inter-reader agreement was assessed with a focus on subgroup analysis considering the different locoregional treatments. NLR values, measured at baseline (T0), 72 h (T1), and 30 days post-procedure (T2), were compared with patients with concordant and discordant LR-TRA assessments. This analysis aimed to identify any association between NLR dynamics and inter-reader agreement on treatment response. Results: The inter-reader agreement in the LR-TRA application was “substantial” in the cases of MWA treatment evaluation (κ = 0.65), and “moderate” in the cases of TAE treatment evaluation (κ = 0.51). The differences in inter-reader agreement were found to be expressions of different levels of NLR mean values in the different time frames evaluated. Three days after treatment, NLR increased significantly in TAE groups. At 30 days, NLR had returned close to baseline levels but with NLR persisting higher in the TAE group. There was a statistically significant difference in NLR between the “mismatch” group (those with discrepant LR-TRA readings) and the “match” group at 3 days (p = 0.004) and late evaluation (30+ days). Conclusions: This study has shown that NLR levels can predict inter-reader discrepancies in LR-TRA assessment and may be translated into different levels of difficult imaging interpretation. Combining LR-TRA and NLR is promising for a more comprehensive assessment of tumor response and inflammatory dynamics.

Verified
Journal Article
Open access
PDF file
EDEleonora Dell’agli
Eleonora Dell’agli
Marco SapienzaMarco Sapienza
Marco Sapienza
MCMirko Domenico Castiglione
Mirko Domenico Castiglione
MMMaria agata Musumeci
Maria agata Musumeci
SPSebiano Pitronaci
Sebiano Pitronaci
GTGianluca Testa
Gianluca Testa
Background: This scoping review analyzes the available literature on pure total talar dislocation, focusing on its epidemiology, clinical presentation, imaging techniques, surgical options, rehabilitation protocols, and complications. Methods: Following the PRISMA-ScR guidelines, a comprehensive search was conducted across the PubMed, Web of Science, and Scopus databases. The search yielded 185 articles, of which 30 satisfied the inclusion criteria and focused on pure total talar dislocation without fractures. Data from each study were extracted, including patient demographics, injury characteristics, treatment methods, and outcomes. Results: The studies included case reports, case series, and reviews. Despite the heterogeneity of the studies, the key findings suggest that early reduction, careful wound management, and soft tissue preservation are crucial in minimizing complications such as avascular necrosis (AVN), post-traumatic arthritis, and infection. The long-term outcomes varied, and the risk of AVN remained high, particularly in cases with compromised blood supply to the talus. Conclusions: Pure total talar dislocation is a rare and challenging condition with no established management protocol. While talar reimplantation and joint fixation offer promising outcomes in preserving function, the risk of complications, particularly AVN, remains significant. Additional research is necessary to standardize treatment protocols and improve clinical outcomes for this rare but severe injury.

2 October 2024 in Preprints.org
Verified
Preprint
Open access
PDF file
EDEleonora Dell’agli
Eleonora Dell’agli
Marco SapienzaMarco Sapienza
Marco Sapienza
MCMirko Domenico Castiglione
Mirko Domenico Castiglione
MMMaria agata Musumeci
Maria agata Musumeci
SPSebiano Pitronaci
Sebiano Pitronaci
GTGianluca Testa
Gianluca Testa
This scoping review aims to systematically examine and analyse the available literature on pure total talar dislocation, focusing on its epidemiology, clinical presentation, imaging techniques, surgical options, rehabilitation protocols, and complications. Following the PRISMA-ScR guidelines, a comprehensive search was conducted across PubMed, Web of Science, and Scopus databases. The search yielded 185 articles, from which 30 met the inclusion criteria, focusing on pure total talar dislocation without fractures. Data from each study were extracted, including patient demographics, injury characteristics, treatment methods, and outcomes. A total of 30 articles were included in this review after screening and quality assessment by five independent reviewers. The studies included case reports, case series, and reviews. Despite the heterogeneity of available studies, key findings suggested that early reduction, careful wound management, and soft tissue preservation are crucial in minimising complications such as avascular necrosis (AVN), post-traumatic arthritis, and infection. Long-term outcomes varied, and the risk of AVN remained high, particularly in cases with compromised blood supply to the talus. Pure total talar dislocation is a rare and challenging condition with no established management protocol. While talar reimplantation and joint fixation offer promising outcomes in preserving function, the risk of complications, particularly AVN, remains significant. Further research is needed to standardise treatment protocols and improve clinical outcomes for this rare but severe injury.

25 July 2026 in MUSCULOSKELETAL SURGERY
Verified
Journal Article
Closed access
PDF file
LLLudovico Lucenti
Ludovico Lucenti
MCMirko Domenico Castiglione
Mirko Domenico Castiglione
MMMaria agata Musumeci
Maria agata Musumeci
AVAndrea Vescio
Andrea Vescio
GRGiuseppe Rovere
Giuseppe Rovere
Vito PavoneVito Pavone
Vito Pavone

12 February 2024 in Preprints.org
Verified
Preprint
Open access
PDF file
SGSerena Maria Chiara Giardina
Serena Maria Chiara Giardina
GTGianluca Testa
Gianluca Testa
ECEnrica Rosalia Cuffaro
Enrica Rosalia Cuffaro
MCMirko Domenico Castiglione
Mirko Domenico Castiglione
Marco SapienzaMarco Sapienza
Marco Sapienza
Vito PavoneVito Pavone
Vito Pavone
Background: Olecranon fractures are common injuries of the upper limb in adults. Simple dis-placed trasverse fractures are generally surgically treated with tension-band wiring (TBW) or plate fixation (PF). The purpose of this retrospective study is to compare the clinical-functional outcome, complications and reoperation rates between TBW and PF for Mayo IIA fractures. Methods: 72 patients treated with PF or TBW at our institution, completed our survey and clinical evaluation and their demographic and clinical data were recorded and analysed. The clini-cal-functional outcomes were evaluated assessing ROMs and three validated scoring systems: the Disabilities of the Arm, Shoulder, and Hand (DASH), the Mayo Elbow Performance Score (MEPS) and the Patient American Shoulder and Elbow Surgeons Standardized Elbow Assess-ment score (pASES-e). Results: 38 patients (53%) underwent TBW and 34 (47%) PF. The mean DASH, MEPS and pASES-e scores were respectively 14.5±17.2, 80.5±14.7 and 83.6±12.4 in the TBW group and 21±21.7, 75.6±15.3 and 75.1±19.2 in the PF group (p=0.16, p=0.17 and p=0.03). The mean duration of surgery and hospitalisation period were longer in the PF group (p=0.002, p=0.37) whereas the complication and reoperation rates were higher after TBW (p=0.15, p=0.24). Conclusion: According to the literature, both TBW and PF resulted comparable valid surgical op-tions for the treatment of simple isolated displaced olecranon fractures, revealing that they both provide good/excellent outcomes with no significant differences.