Designing and installing efficient grounding systems in power distribution networks is considered a complex and crucial task to ensure the reliable operation of power-protective schemes while mitigating hazardous potentials arising from faults, thereby safeguarding both personnel and equipment. This paper aims to offer guidance on designing effective grounding systems in distribution networks by assessing the influence of parameters such as soil structure, fault current magnitude, and fault clearing time. This involves proposing a more precise methodology for calculating hazardous potentials, leveraging software tools like PowerFactory, to accurately determine short-circuit (SC) currents and fault clearing times at specific locations where grounding grids are to be installed. Consequently, Distribution System Operators (DSOs) can design tailored grounding systems that optimize techno-economic considerations without unnecessary over-dimensioning, accounting for the unique characteristics of the Medium-Voltage (MV) Line and soil structure.