Derek Wu

Dr. Derek Wu

orcid

Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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23 February 2024 in The Ultrasound Journal
Verified
Journal Article
Open access
PDF file
RPRoss Prager
Ross Prager
DWDerek Wu
Derek Wu
GGGary Garber
Gary Garber
PFP. J. Finestone
P. J. Finestone
CZCathy Zang
Cathy Zang
RARobert Arntfield
Robert Arntfield
Background: Point-of-care ultrasound (POCUS) has become a core diagnostic tool for many physicians due to its portability, excellent safety profile, and diagnostic utility. Despite its growing use, the potential risks of POCUS use should be considered by providers. We analyzed the Canadian Medical Protective Association (CMPA) repository to identify medico-legal cases arising from the use of POCUS. Methods: We retrospectively searched the CMPA closed-case repository for cases involving diagnostic POCUS between January 1st, 2012 and December 31st, 2021. Cases included civil-legal actions, medical regulatory authority (College) cases, and hospital complaints. Patient and physician demographics, outcomes, reason for complaint, and expert-identified contributing factors were analyzed. Results: From 2012 to 2021, there were 58,626 closed medico-legal cases in the CMPA repository with POCUS determined to be a contributing factor for medico-legal action in 15 cases; in all cases the medico-legal outcome was decided against the physicians. The most common reasons for patient complaints were diagnostic error, deficient assessment, and failure to perform a test or intervention. Expert analysis of these cases determined the most common contributing factors for medico-legal action was failure to perform POCUS when indicated (7 cases, 47%); however, medico-legal action also resulted from diagnostic error, incorrect sonographic approach, deficient assessment, inadequate skill, inadequate documentation, or inadequate reporting. Conclusions: Although the most common reason associated with the medico-legal action in these cases is failure to perform POCUS when indicated, inappropriate use of POCUS may lead to medico-legal action. Due to limitations in granularity of data, the exact number of civil-legal, College cases, and hospital complaints for each contributing factor is unavailable. To enhance patient care and mitigate risk for providers, POCUS should be carefully integrated with other clinical information, performed by providers with adequate skill, and carefully documented.

22 May 2024 in Diagnostics
Verified
Journal Article
Open access
PDF file
DWDerek Wu
Derek Wu
DSDelaney Smith
Delaney Smith
BVBlake VanBerlo
Blake VanBerlo
ARAmir Roshankar
Amir Roshankar
HLHoseok Lee
Hoseok Lee
RARobert Arntfield
Robert Arntfield
Deep learning (DL) models for medical image classification frequently struggle to generalize to data from outside institutions. Additional clinical data are also rarely collected to comprehensively assess and understand model performance amongst subgroups. Following the development of a single-center model to identify the lung sliding artifact on lung ultrasound (LUS), we pursued a validation strategy using external LUS data. As annotated LUS data are relatively scarce—compared to other medical imaging data—we adopted a novel technique to optimize the use of limited external data to improve model generalizability. Externally acquired LUS data from three tertiary care centers, totaling 641 clips from 238 patients, were used to assess the baseline generalizability of our lung sliding model. We then employed our novel Threshold-Aware Accumulative Fine-Tuning (TAAFT) method to fine-tune the baseline model and determine the minimum amount of data required to achieve predefined performance goals. A subgroup analysis was also performed and Grad-CAM++ explanations were examined. The final model was fine-tuned on one-third of the external dataset to achieve 0.917 sensitivity, 0.817 specificity, and 0.920 area under the receiver operator characteristic curve (AUC) on the external validation dataset, exceeding our predefined performance goals. Subgroup analyses identified LUS characteristics that most greatly challenged the model’s performance. Grad-CAM++ saliency maps highlighted clinically relevant regions on M-mode images. We report a multicenter study that exploits limited available external data to improve the generalizability and performance of our lung sliding model while identifying poorly performing subgroups to inform future iterative improvements. This approach may contribute to efficiencies for DL researchers working with smaller quantities of external validation data.


15 April 2025 in POCUS Journal
Verified
Journal Article
Open access
PDF file
RPRoss Prager
Ross Prager
HCHans Clausdorff
Hans Clausdorff
DSDelaney Smith
Delaney Smith
DWDerek Wu
Derek Wu
RARobert Arntfield
Robert Arntfield
Background: Chest point of care ultrasound (POCUS) is a first-line diagnostic test to identify lung sliding, an important artifact to diagnose or rule out pneumothorax. Despite enthusiastic adoption of this modality, the interrater reliability for physicians to identify lung sliding is unknown. Additionally, the relative diagnostic performance of physicians interpreting B-mode and M-mode ultrasound is unclear. We sought to determine the interrater reliability of physicians to detect lung sliding on B-mode and M-mode POCUS. Methods: We performed a cross-sectional interrater agreement study surveying acute care physicians on their interpretation of 20 B-mode and M-mode POCUS clips. Two experienced clinicians determined the reference standard diagnosis. Respondents reported their interpretation of each POCUS B-mode clip or M-mode image. The primary outcome was the interrater agreement, determined by an intra-class correlation coefficient (ICC). Results: From September to November 2023, there were 20 survey respondents. Fourteen (70%) respondents were resident physicians. Respondents were confident or very confident in their skill performing chest POCUS in 14 (70%) cases, with 19 (90%) performing chest POCUS every week or more frequently. The ICC on B-mode was 0.44 and for M-mode was 0.43, indicating moderate agreement. There were no significant differences in interrater reliability between subgroups of confidence or experience. Conclusion: There is only moderate interrater reliability between clinicians to diagnose lung sliding. Clinicians have superior accuracy on B-mode compared to M-mode clips.

2 March 2026 in Journal of Intensive Care Medicine
Verified
Journal Article
Open access
DWDerek Wu
Derek Wu
RARobert Arntfield
Robert Arntfield
SMScott J. Millington
Scott J. Millington
Artificial intelligence (AI) is increasingly integrated into point-of-care ultrasound (POCUS) to enhance its utility in critical care settings. This manuscript explores the current state of AI applications in POCUS, focusing on key domains such as image acquisition, image interpretation, education, task automation, procedural guidance, program development, and quality assurance. AI-driven tools can potentially improve image quality, provide real-time feedback, and assist in the interpretation of ultrasound images, thereby democratizing the use of POCUS across varying levels of operator expertise. This narrative review highlights relevant studies demonstrating the clinical utility of AI in POCUS, discusses the challenges that remain, and provides insights into future developments. The goal is to equip intensivists with a comprehensive understanding of how AI can support POCUS practice today and what advancements are on the horizon.