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Prof. Dr. José António Belo
NOVA Medical School | Faculdade de Ciências Médicas, Lisbon, Lisboa, Portugal
'%3e%3cpath%20d='M22.1642%2019.0924C21.7317%2018.068%2021.1041%2017.1375%2020.3163%2016.3527C19.5309%2015.5656%2018.6006%2014.9381%2017.5766%2014.5048C17.5674%2014.5002%2017.5582%2014.4979%2017.5491%2014.4933C18.9774%2013.4616%2019.9059%2011.7811%2019.9059%209.88504C19.9059%206.74408%2017.3611%204.19922%2014.2201%204.19922C11.0792%204.19922%208.53429%206.74408%208.53429%209.88504C8.53429%2011.7811%209.46282%2013.4616%2010.8912%2014.4956C10.882%2014.5002%2010.8728%2014.5025%2010.8636%2014.5071C9.83652%2014.9404%208.91487%2015.5617%208.1239%2016.355C7.33685%2017.1404%206.70933%2018.0707%206.276%2019.0947C5.85031%2020.0972%205.62072%2021.172%205.59967%2022.2609C5.59905%2022.2853%205.60335%2022.3097%205.61229%2022.3325C5.62123%2022.3553%205.63465%2022.376%205.65174%2022.3935C5.66883%2022.4111%205.68926%2022.425%205.71182%2022.4345C5.73437%2022.444%205.7586%2022.4489%205.78308%2022.4489H7.15868C7.25956%2022.4489%207.3398%2022.3686%207.3421%2022.2701C7.38795%2020.5001%208.09868%2018.8425%209.35506%2017.5861C10.655%2016.2862%2012.3814%2015.5709%2014.2201%2015.5709C16.0588%2015.5709%2017.7852%2016.2862%2019.0852%2017.5861C20.3415%2018.8425%2021.0523%2020.5001%2021.0981%2022.2701C21.1004%2022.3709%2021.1807%2022.4489%2021.2815%2022.4489H22.6571C22.6816%2022.4489%2022.7058%2022.444%2022.7284%2022.4345C22.751%2022.425%2022.7714%2022.4111%2022.7885%2022.3935C22.8056%2022.376%2022.819%2022.3553%2022.8279%2022.3325C22.8369%2022.3097%2022.8412%2022.2853%2022.8406%2022.2609C22.8176%2021.165%2022.5907%2020.0989%2022.1642%2019.0924ZM14.2201%2013.8284C13.1678%2013.8284%2012.1773%2013.418%2011.4322%2012.6729C10.6871%2011.9278%2010.2767%2010.9374%2010.2767%209.88504C10.2767%208.83271%2010.6871%207.84227%2011.4322%207.09715C12.1773%206.35204%2013.1678%205.94165%2014.2201%205.94165C15.2724%205.94165%2016.2629%206.35204%2017.008%207.09715C17.7531%207.84227%2018.1635%208.83271%2018.1635%209.88504C18.1635%2010.9374%2017.7531%2011.9278%2017.008%2012.6729C16.2629%2013.418%2015.2724%2013.8284%2014.2201%2013.8284Z'%20fill='%238590A2'/%3e%3c/g%3e%3c/svg%3e)
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Academic Career Length
34Years (1993-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 February 2000 in Nature
Journal Article
DBDaniel Bachiller
Daniel BachillerJKJohn Klingensmith
John Klingensmith
CKC. Kemp
C. Kemp
JBJosé António Belo
José António BeloRAR. M. Anderson
R. M. Anderson
ERE. M. De Robertis
E. M. De Robertis
+5
1 November 1997 in Mechanisms of Development
Journal Article
JBJosé António Belo
José António BeloTBTewis Bouwmeester
Tewis Bouwmeester
LLLuc Leyns
Luc LeynsNKNathalie Kertesz
Nathalie Kertesz
MGMichael Gallo
Michael Gallo
EREddy M De Robertis
Eddy M De Robertis
+1
12 October 2012 in Science
Journal Article
SYSatoko Yoshiba
Satoko Yoshiba
HSHidetaka Shiratori
Hidetaka Shiratori
IKIvana Y. Kuo
Ivana Y. KuoAKAiko Kawasumi
Aiko KawasumiKSKyosuke Shinohara
Kyosuke Shinohara
HHHiroshi Hamada
Hiroshi Hamada +9
Distinguishing Right from Left: In most vertebrates during embryonic development, rotational movement of the cilia within a structure in the embryo, known as the node, generates unidirectional flow required for future left-right asymmetry of the internal organs. The flow may transport a determinant molecule or provide mechanical force. However, it is not clear how the flow is sensed.
Yoshiba
et al.
(p. 226 , published online 13 September; see the Perspective by Norris and Grimes ) show that nodal flow in mouse embryos is sensed by the cilia of perinodal cells located at the edge of the node, in a manner dependent on Pkd2, a Ca 2+ -permeable cation channel that has been implicated in polycystic kidney disease in humans.
1 October 2004 in Genes & Development
Journal Article
SMSara Marques
Sara MarquesABAna Cristina Borges
Ana Cristina BorgesASAna Cristina Silva
Ana Cristina Silva
SFSandra Freitas
Sandra Freitas
MCMichelangelo Cordenonsi
Michelangelo CordenonsiJBJosé António Belo
José António BeloCorrect establishment of the left/right (L/R) body asymmetry in the mouse embryo requires asymmetric activation of the evolutionarily conserved Nodal signaling cascade in the left lateral plate mesoderm (L-LPM). Furthermore, the presence of Nodal in the node is essential for its own expression in the L-LPM. Here, we have characterized the function of cerl-2, a novel Nodal antagonist, which displays a unique asymmetric expression on the right side of the mouse node. cerl-2 knockout mice display multiple laterality defects including randomization of the L/R axis. These defects can be partially rescued by removing one nodal allele. Our results demonstrate that Cerl-2 plays a key role in restricting the Nodal signaling pathway toward the left side of the mouse embryo by preventing its activity in the right side.
1 November 2005 in Developmental Cell
Journal Article
CKChiharu Kimura-Yoshida
Chiharu Kimura-Yoshida
HNHiroshi Nakano
Hiroshi Nakano
DODaiji Okamura
Daiji Okamura
KNKazuki Nakao
Kazuki Nakao
SYShigenobu Yonemura
Shigenobu Yonemura
IMIsao Matsuo
Isao Matsuo +3
1 January 2012 in Nature Communications
Journal Article
TNTetsuya Nakamura
Tetsuya NakamuraDSDaisuke Saito
Daisuke SaitoAKAiko Kawasumi
Aiko KawasumiKSKyosuke Shinohara
Kyosuke Shinohara
YAYasuko Asai
Yasuko Asai
HHHiroshi Hamada
Hiroshi Hamada +5
Breaking of left–right symmetry in mouse embryos requires fluid flow at the node, but the precise action of the flow has remained unknown. Here we show that the left–right asymmetry of Cerl2 expression around the node, a target of the flow, is determined post-transcriptionally by decay of Cerl2 mRNA in a manner dependent on its 3′ untranslated region. Cerl2 mRNA is absent specifically from the apical region of crown cells on the left side of the node. Preferential decay of Cerl2 mRNA on the left is initiated by the leftward flow and further enhanced by the operation of Wnt-Cerl2 interlinked feedback loops, in which Wnt3 upregulates Wnt3 expression and promotes Cerl2 mRNA decay, whereas Cerl2 promotes Wnt degradation. Mathematical modelling and experimental data suggest that these feedback loops behave as a bistable switch that can amplify in a noise-resistant manner a small bias conferred by fluid flow.
About Me
José António Belo is a full professor of cellular and molecular biology at NOVA Medical School/Universidade NOVA de Lisboa (NMS/UNL) where, since 2013, he has served as the Director of the Ph.D. Program "ProRegeM". He teaches and is the course director of molecular and cellular biology, developmental biology, stem cells and development, and new cellular and molecular therapies. He is a principal investigator and head of the Stem Cells and Development Lab. Currently, he focuses his studies on the induction and control of myocardium and coronary vasculature development, organogenesis, and function. The Belo lab has been using the most up-to-date technologies in molecular embryology and regenerative medicine, including the generation and analysis of KO mouse lines, mouse and human ES/iPS cell differentiation, and CRISPR/CAS9 technologies. They aim to understand the etiology and treatment of cardiovascular disease from a developmental biology, genetics, and physiology perspective with regenerative medicine purposes.