Cocaine is one of the most often used psychoactive drugs worldwide, being extracted from the leaves of Erytroxylus coca plant. Its abusive use can trigger several consequences for the human body, including the oral cavity. To identify the oral disorders that are most commonly found in individuals who abuse cocaine, in addition to the main diagnostic and treatment methods. An integrative review was carried out on the databases: LILACS, BBO, LIS, MEDLINE, SciELO, Science Direct and PubMed. The following keywords were used: "Cocaína", "Boca", "Palato" and "Odontologia", together with their synonyms and variations in English, obtained from DeCS and MeSH. The inclusion criteria were original articles, articles in Portuguese, English and Spanish, studies involving individuals, without restriction related to the year of publication. Animal studies, literature reviews, book chapters, theses and dissertations were excluded. In total, 1373 records were identified. Of these, 22 articles were selected to comprise the review. Several oral alterations caused by cocaine abuse were found, primarily perforation of the palate, predisposition to periodontal diseases, temporomandibular disorders, bruxism, damage to oral tissues, dental caries, destructive lesions of the facial midline, xerostomia and ageusia. Among the diagnostic methods used by the professionals, anamnesis, intraoral examinations and head and neck computed tomography were the most frequently mentioned. As for treatment, in patients with palatal perforation, the reconstruction of the affected area or the use of prosthetic obturators is carried out. The management of these patients is not an easy task, as many of the users do not even seek professional help. The health professionals must be able to recognize these manifestations and alterations to establish timely and accurate diagnosis and treatment planning.

Artificial Intelligence (AI) simulates human intelligence in machines capable of rational response and actions. AI’s growth in healthcare, particularly in dentistry, has been remarkable in aiding clinical practices from appointment scheduling to treatment outcome predictions. In orthodontics, AI effectively handles tasks such as automated landmark detection, diagnosing orthodontic needs, assessing maxillary constriction, and selecting appliances. ChatGPT, an AI-based program by OpenAI, excels in generating human-like responses, making it useful across many applications, including those in dentistry. AI enhances personalised patient communication, supports diagnosis and decision-making, digitises patient data, and aids in disease prevention and treatment. In addition, ChatGPT offers support in personalised care, billing, and patient health monitoring. Patients benefit from its help in finding providers, scheduling initial appointments, accessing health information, improving healthcare access and service effectiveness. However, there are limitations. ChatGPT sometimes produces nonsensical responses and poses privacy risks associated with patient data. Generated medical advice might not therefore match professional expertise. Despite these issues, if trained properly, ChatGPT could significantly enhance medical knowledge dissemination. Future studies should weigh the benefits of AI against its risks, and users must verify AI-generated information with reliable sources to ensure effective patient care.