South Brazilian organic propolis (OP), which has never been studied before, was assessed and its chemical composition, scavenging potential of reactive oxygen species, antimicrobial and anti-inflammatory activities are herein presented. Based on the chemical profile obtained using HPLC, OP was grouped into seven variants (OP1–OP7) and all of them exhibited high scavenging activity, mainly against superoxide and hypochlorous acid species. OP1, OP2, and OP3 had the smallest minimal inhibitory concentration (MIC) against Gram-positive bacteria Streptococcus mutans, Streptococcus oralis, and Streptococcus aureus (12.5–100 μg/mL). OP1, OP2, OP3, and OP4 were more effective against Pseudomonas aeruginosa (Gram-negative), with MIC values ranging from 100 to 200 μg/mL. OP6 showed anti-inflammatory activity by decreasing NF-kB activation and TNF-α release in RAW 264.7 macrophages, and expressing the NF-κB-luciferase reporter stable gene. Therefore, south Brazilian OP can be considered an excellent source of bioactive compounds with great potential of application in the pharmaceutical and food industry.

Liquid-Crystalline Systems represent active compounds delivery systems that may be able to overcome the physical barrier of the skin, especially represented by the stratum corneum. To obtain these systems, aqueous and oily components are used with surfactants. Of the different association structures in such systems, the liquid-crystalline offer numerous advantages to a topical product. This manuscript presents the development of liquid-crystalline systems consisting, in which the oil component is olive oil, its rheological characterizations, and the location of liquid crystals in its phase map. Cytotoxic effects were evaluated using J-774 mouse macrophages as the cellular model. A phase diagram to mix three components with different proportions was constructed. Two liquid crystalline areas were found with olive oil in different regions in the ternary diagram with two nonionic surfactants, called SLC1 (S1) and SLC2 (S2). These systems showed lamellar liquid crystals that remained stable during the entire analysis time. The systems were also characterized rheologically with pseudoplastic behavior without thixotropy. The texture and bioadhesion assays showed that formulations were similar statistically (p < 0.05), indicating that the increased amount of water in S2 did not interfere with the bioadhesive properties of the systems. In vitro cytotoxic assays showed that formulations did not present cytotoxicity. Olive oil-based systems may be a promising platform for skin delivery of drugs.

A própolis é um material resinoso coletado de plantas e cascas de árvores pelas abelhas Apis mellifera, é dotada de substâncias biologicamente ativas com propriedades antioxidantes, anti-inflamatória, antitumoral e antimicrobiana. O objetivo desse trabalho consistiu em avaliar a segurança alimentar do uso da própolis na prevenção e no tratamento de doenças. O levantamento da literatura estudada foi feito de modo a abordar a relevância das propriedades terapêuticas da própolis através dos vários estudos científicos bem como possíveis efeitos colaterais pelo uso indiscriminado, podendo resultar em reações alérgicas graves. Desta forma, se faz necessário a discussão do tema por corroborar com a saúde pública.

O objetivo dessa revisão consistiu na discussão das interações bioquímicas de proteínas, peptídeos, lipídios, e ácidos graxos encontrados nas carnes bovina, suína e mariscos, uma vez que esses tipos de carnes são fontes de muitos nutrientes. Durante muitas décadas, as pesquisas têm estabelecido práticas de manejo do animal e indicadores de qualidade para minimizar a incidência de carnes de qualidade inferior. Os atributos da qualidade de carnes são grandemente determinados pela taxa e extensão do declínio do pH no post-mortem. As interações bioquímicas do post-mortem do animal e o processo de congelamento dessa carne são responsáveis pelas mudanças da qualidade nutricional desse alimento, bem como seu tempo de armazenamento. Assim sendo, a qualidade da carne pode apresentar um impacto positivo ou negativo na segurança alimentar.