Epicardial adipose tissue (EAT) is a fat deposit surrounding the heart and located under the visceral layer of the pericardium. Due to its unique features, the contribution of EAT to the pathogenesis of cardiovascular and metabolic disorders is extensively studied. Especially, EAT can be associated with the onset and development of coronary artery disease, myocardial infarction and post-infarct heart failure which all are significant problems for public health. In this article, we focus on the mechanisms of how EAT impacts acute coronary syndromes. Particular emphasis was placed on the role of inflammation and adipokines secreted by EAT. Moreover, we present how EAT affects the remodeling of the heart following myocardial infarction. We further review the role of EAT as a source of stem cells for cardiac regeneration. In addition, we describe the imaging assessment of EAT, its prognostic value, and its correlation with the clinical characteristics of patients.

The β3-adrenergic receptor is an exceptional member of the β-adrenergic receptor family. Recent findings suggest that it may play a more significant role in the cardiovascular system than previously recognized, partly through its potential anti-inflammatory actions. For this reason, it has been extensively studied as a potential target in cardiovascular therapy. In this review, we focus on the β3-adrenergic receptor agonists and their pharmacodynamics regarding receptor binding and activation. We then describe the mechanisms of action mediated by the β3-adrenergic receptor in blood vessels and in the heart under both physiological and pathological conditions. We particularly concentrate on the therapeutic potential in the arterial, pulmonary, and portal hypertension as well as cardiac arrhythmias, ischemia, and heart failure, considering both receptor agonism and antagonism.

Poststreptococcal glomerulonephritis is a rare condition in developed countries. Skin rash is a common symptom associated with a variety of diseases. Due to non-specific features of poststreptococcal glomerulonephritis, the condition requires a broad differential diagnosis. A case is presented involving a 19-year old woman who was admitted to the hospital after pharyngeal infection, with symptoms indicative of acute kidney injury. The patient exhibited lower limb oedema, dyspnoea, hypertension and an atypical skin rash. The patient was diagnosed with poststreptococcal glomerulonephritis. Therapeutic interventions, including antibiotic therapy and symptomatic treatment, resulted in complete recovery. This case highlights the importance of accurately determining the etiology of symptoms, as skin rash is an uncommon manifestation in poststreptococcal glomerulonephritis. The patient's perspective and a thorough interview are of critical value. A broad differential diagnosis and multidisciplinary approach are crucial for establishing the correct diagnosis.