The skin is crucial for homeostasis and body defense, requiring quick healing to maintain internal balance. Initially used for bone repair, calcium hydroxyapatite (HAp) is now being studied for soft tissue engineering. This literature review investigated HAp’s role in tissue repair through searches on PubMed, Scopus (Elsevier), Science Direct, Springer Link, and Google Scholar databases without time restrictions, using keywords “hydroxyapatite AND skin AND wound” and “hydroxyapatite AND skin repair”. Inclusion criteria encompassed in vivo studies in humans and animals, English publications, full access, and sufficient data on HAp’s role in tissue repair. Exclusions included duplicates, unrelated articles, editor letters, reviews, comments, conference abstracts, dissertations, and theses. Out of the 472 articles initially identified, 139 met the inclusion criteria, with 21 focusing on HAp for tissue repair. Findings indicate that HAp and nano-HAp in skin regeneration are promising, especially when combined with other biomaterials, offering antimicrobial and anti-inflammatory benefits and stimulating angiogenesis. This suggests their potential application in dermatology, surgery, and dentistry, extending HAp’s versatility from hard tissues to enhancing critical properties for soft tissue repair and accelerating healing.