Electronic Health Records (EHRs) are a valuable asset to facilitate clinical research and point of care applications; however, many challenges such as data privacy concerns impede its optimal utilization. Deep generative models, particularly Generative Adversarial Networks (GANs), show great promise in generating synthetic EHR data by learning underlying data distributions while achieving excellent performance and addressing these challenges. This work aims to survey the major developments in various applications of GANs for EHRs and provides an overview of the proposed methodologies. For this purpose, we combine perspectives from healthcare applications and machine learning techniques in terms of source datasets and the fidelity and privacy evaluation of the generated synthetic datasets. We also compile a list of the metrics and datasets used by the reviewed works, which can be utilized as benchmarks for future research in the field. We conclude by discussing challenges in GANs for EHRs development and proposing recommended practices. We hope that this work motivates novel research development directions in the intersection of healthcare and machine learning.

Evidence-based medicine (EBM) represents a paradigm of providing patient care grounded in the most current and rigorously evaluated research. Recent advances in large language models (LLMs) offer a potential solution to transform EBM by automating labor-intensive tasks and thereby improving the efficiency of clinical decision-making. This study explores integrating LLMs into the key stages in EBM, evaluating their ability across evidence retrieval (PICO extraction, biomedical question answering), synthesis (summarizing randomized controlled trials), and dissemination (medical text simplification). We conducted a comparative analysis of seven LLMs, including both proprietary and open-source models, as well as those fine-tuned on medical corpora. Specifically, we benchmarked the performance of various LLMs on each EBM task under zero-shot settings as baselines, and employed prompting techniques, including in-context learning, chain-of-thought reasoning, and knowledge-guided prompting to enhance their capabilities. Our extensive experiments revealed the strengths of LLMs, such as remarkable understanding capabilities even in zero-shot settings, strong summarization skills, and effective knowledge transfer via prompting. Promoting strategies such as knowledge-guided prompting proved highly effective (e.g., improving the performance of GPT-4 by 13.10% over zero-shot in PICO extraction). However, the experiments also showed limitations, with LLM performance falling well below state-of-the-art baselines like PubMedBERT in handling named entity recognition tasks. Moreover, human evaluation revealed persisting challenges with factual inconsistencies and domain inaccuracies, underscoring the need for rigorous quality control before clinical application. This study provides insights into enhancing EBM using LLMs while highlighting critical areas for further research. The code is publicly available on Github.

Accurate prediction of reservoir landslide displacements is crucial for early warning and hazard prevention. Current machine learning (ML) paradigms for predicting landslide displacement demonstrate superior performance, while often relying on various feature engineering techniques, such as decomposing into different temporal lags and feature selection. This study investigates the impact of various feature selection techniques on the performance of ML algorithms for landslide displacement prediction. The Shuping and Baishuihe landslides in China’s Three Gorges Reservoir Area are used to comprehensively benchmark four prevalent ML algorithms. Both static ML models, including backpropagation neural network (BPNN), support vector machine (SVM), and dynamic models, such as long short-term memory (LSTM), and gated recurrent unit (GRU), are included. Each ML model is evaluated under three feature engineering techniques: raw multivariate time series, and feature selection under maximal information coefficient-partial autocorrelation function (MIC-PACF), or grey relational analysis-PACF (GRA-PACF). The results demonstrate that appropriate feature selection methods could significantly improve the performance of static ML models. In contrast, dynamic models effectively leverage inherent capabilities in capturing temporal dynamics within raw multivariate time series, seeing marginal gains with extensive feature engineering compared to no feature selection strategy. The optimal feature selection approach varies based on the ML model and specific landslide, highlighting the importance of case-specific assessments. The findings in this study offer guidance on integrating feature selection techniques with different machine learning models to maximize the robustness and generalizability of data-driven landslide displacement prediction frameworks.

Background: Observational biomedical studies facilitate a new strategy for large-scale electronic health record (EHR) utilization to support precision medicine. However, data label inaccessibility is an increasingly important issue in clinical prediction, despite the use of synthetic and semisupervised learning from data. Little research has aimed to uncover the underlying graphical structure of EHRs. Objective: A network-based generative adversarial semisupervised method is proposed. The objective is to train clinical prediction models on label-deficient EHRs to achieve comparable learning performance to supervised methods. Methods: Three public data sets and one colorectal cancer data set gathered from the Second Affiliated Hospital of Zhejiang University were selected as benchmarks. The proposed models were trained on 5% to 25% labeled data and evaluated on classification metrics against conventional semisupervised and supervised methods. The data quality, model security, and memory scalability were also evaluated. Results: The proposed method for semisupervised classification outperforms related semisupervised methods under the same setup, with the average area under the receiver operating characteristics curve (AUC) reaching 0.945, 0.673, 0.611, and 0.588 for the four data sets, respectively, followed by graph-based semisupervised learning (0.450, 0.454, 0.425, and 0.5676, respectively) and label propagation (0.475,0.344, 0.440, and 0.477, respectively). The average classification AUCs with 10% labeled data were 0.929, 0.719, 0.652, and 0.650, respectively, comparable to that of the supervised learning methods logistic regression (0.601, 0.670, 0.731, and 0.710, respectively), support vector machines (0.733, 0.720, 0.720, and 0.721, respectively), and random forests (0.982, 0.750, 0.758, and 0.740, respectively). The concerns regarding the secondary use of data and data security are alleviated by realistic data synthesis and robust privacy preservation. Conclusions: Training clinical prediction models on label-deficient EHRs is indispensable in data-driven research. The proposed method has great potential to exploit the intrinsic structure of EHRs and achieve comparable learning performance to supervised methods.

Hydrodynamic pressure is often a crucial factor in the evaluation of slope stability analysis, especially for many rainfall-triggered landslides. Nevertheless, hydrodynamic pressure is rarely considered in the traditional limit equilibrium slice method of slope stability analysis since effective and reliable hydrodynamic pressure data are often lacking in practice. Moreover, efficient methods to involve these data in slope stability analysis are an urgent need. To overcome these concerns, the flow velocity and direction system (FVDS) is employed to measure the groundwater flow velocity, which can be used to generate hydrodynamic pressure samples at different monitoring points. Based on these samples, the hydrodynamic pressure of each soil strip is estimated using artificial neural networks (ANNs). Afterward, an improved Bishop method that considers hydrodynamic pressure is proposed. The effectiveness and significance of the proposed method are illustrated with a case study, the Fanshantou landslide in Zhejiang Province, China. The safety factor before and after taking drainage countermeasures is also calculated and compared. The results indicate that hydrodynamic pressure plays an important role in the stability analysis of the Fanshantou landslide. Compared with the classical Bishop method, the improved method is shown to agree better with the actual deformation characteristics of the landslide.