Valentina Ciappolino

Dr. Valentina Ciappolino

Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Department of Neurosciences and Mental Health, 20122 Milan, Italy.
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Research Focus & Metrics

Academic Career Length

12Years (2015-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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31 May 2018 in Nutrients
Verified
Journal Article
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SSSilvia Scaglioni
Silvia Scaglioni
VCValentina De Cosmi
Valentina De Cosmi
VCValentina Ciappolino
Valentina Ciappolino
Fabio ParazziniFabio Parazzini
Fabio Parazzini
Paolo BrambillaPaolo Brambilla
Paolo Brambilla
Carlo AgostoniCarlo Agostoni
Carlo Agostoni
Relevant factors involved in the creation of some children’s food preferences and eating behaviours have been examined in order to highlight the topic and give paediatricians practical instruments to understand the background behind eating behaviour and to manage children’s nutrition for preventive purposes. Electronic databases were searched to locate and appraise relevant studies. We carried out a search to identify papers published in English on factors that influence children’s feeding behaviours. The family system that surrounds a child’s domestic life will have an active role in establishing and promoting behaviours that will persist throughout his or her life. Early-life experiences with various tastes and flavours have a role in promoting healthy eating in future life. The nature of a narrative review makes it difficult to integrate complex interactions when large sets of studies are involved. In the current analysis, parental food habits and feeding strategies are the most dominant determinants of a child’s eating behaviour and food choices. Parents should expose their offspring to a range of good food choices while acting as positive role models. Prevention programmes should be addressed to them, taking into account socioeconomic aspects and education.

4 January 2016 in Nutrients
Verified
Journal Article
Open access
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LLLotte Lauritzen
Lotte Lauritzen
Paolo BrambillaPaolo Brambilla
Paolo Brambilla
AMAlessandra Mazzocchi
Alessandra Mazzocchi
LHLaurine B. S. Harsløf
Laurine B. S. Harsløf
VCValentina Ciappolino
Valentina Ciappolino
Carlo AgostoniCarlo Agostoni
Carlo Agostoni
Docosahexaenoic acid (DHA) is a structural constituent of membranes specifically in the central nervous system. Its accumulation in the fetal brain takes place mainly during the last trimester of pregnancy and continues at very high rates up to the end of the second year of life. Since the endogenous formation of DHA seems to be relatively low, DHA intake may contribute to optimal conditions for brain development. We performed a narrative review on research on the associations between DHA levels and brain development and function throughout the lifespan. Data from cell and animal studies justify the indication of DHA in relation to brain function for neuronal cell growth and differentiation as well as in relation to neuronal signaling. Most data from human studies concern the contribution of DHA to optimal visual acuity development. Accumulating data indicate that DHA may have effects on the brain in infancy, and recent studies indicate that the effect of DHA may depend on gender and genotype of genes involved in the endogenous synthesis of DHA. While DHA levels may affect early development, potential effects are also increasingly recognized during childhood and adult life, suggesting a role of DHA in cognitive decline and in relation to major psychiatric disorders.

3 June 2020 in Nutrients
Verified
Journal Article
Open access
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Andrea BotturiAndrea Botturi
Andrea Botturi
VCValentina Ciappolino
Valentina Ciappolino
Giuseppe DelvecchioGiuseppe Delvecchio
Giuseppe Delvecchio
ABAndrea Boscutti
Andrea Boscutti
BVBianca Viscardi
Bianca Viscardi
Paolo BrambillaPaolo Brambilla
Paolo Brambilla
Introduction: Magnesium is an essential cation involved in many functions within the central nervous system, including transmission and intracellular signal transduction. Several studies have shown its usefulness in neurological and psychiatric diseases. Furthermore, it seems that magnesium levels are lowered in the course of several mental disorders, especially depression. Objectives: In this study, we wish to evaluate the presence of a relationship between the levels of magnesium and the presence of psychiatric pathology as well as the effectiveness of magnesium as a therapeutic supplementation. Methods: A systematic search of scientific records concerning magnesium in psychiatric disorders published from 2010 up to March 2020 was performed. We collected a total of 32 articles: 18 on Depressive Disorders (DD), four on Anxiety Disorders (AD), four on Attention Deficit Hyperactivity Disorder (ADHD), three on Autism Spectrum Disorder (ASD), one on Obsessive–Compulsive Disorder (OCD), one on Schizophrenia (SCZ) and one on Eating Disorders (ED). Results: Twelve studies highlighted mainly positive results in depressive symptoms. Seven showed a significant correlation between reduced plasma magnesium values and depression measured with psychometric scales. Two papers reported improved depressive symptoms after magnesium intake, two in association with antidepressants, compared to controls. No significant association between magnesium serum levels and panic or Generalized Anxiety Disorder (GAD) patients, in two distinct papers, was found. In two other papers, a reduced Hamilton Anxiety Rating Scale (HAM-A) score in depressed patients correlated with higher levels of magnesium and beneficial levels of magnesium in stressed patients was found. Two papers reported low levels of magnesium in association with ADHD. Only one of three papers showed lower levels of magnesium in ASD. ED and SCZ reported a variation in magnesium levels in some aspects of the disease. Conclusion: The results are not univocal, both in terms of the plasma levels and of therapeutic effects. However, from the available evidence, it emerged that supplementation with magnesium could be beneficial. Therefore, it is necessary to design ad hoc clinical trials to evaluate the efficacy of magnesium alone or together with other drugs (antidepressants) in order to establish the correct use of this cation with potential therapeutic effects.

Verified
Journal Article
Open access
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Carlo AgostoniCarlo Agostoni
Carlo Agostoni
MNMaria Nobile
Maria Nobile
VCValentina Ciappolino
Valentina Ciappolino
Giuseppe DelvecchioGiuseppe Delvecchio
Giuseppe Delvecchio
ATAlessandra Tesei
Alessandra Tesei
Paolo BrambillaPaolo Brambilla
Paolo Brambilla
In this systematic review, we will consider and debate studies that have explored the effects of ω-3 polyunsaturated fatty acids (PUFAs) in three major, and somehow related, developmental psychiatric disorders: Autism, Attention Deficit and Hyperactivity disorder and Psychosis. The impact of ω-3 PUFAs on clinical symptoms and, if possible, brain trajectory in children and adolescents suffering from these illnesses will be reviewed and discussed, considering the biological plausibility of the effects of omega-3 fatty acids, together with their potential perspectives in the field. Heterogeneity in study designs will be discussed in the light of differences in results and interpretation of studies carried out so far.


1 June 2018 in Journal of Affective Disorders
Verified
Journal Article
Closed access
AAA. Carlo Altamura
A. Carlo Altamura
EMEleonora Maggioni
Eleonora Maggioni
TDTaj Dhanoa
Taj Dhanoa
VCValentina Ciappolino
Valentina Ciappolino
RPRiccardo A. Paoli
Riccardo A. Paoli
Paolo BrambillaPaolo Brambilla
Paolo Brambilla