The administration of corticosteroids may have possible hazards, ranging from minor adverse medication reactions to more serious considerations. We aimed to assess levels of public awareness concerning corticosteroid use, side effects, and predictors of its use. A cross-sectional study was conducted online throughout the period of May to July 2023. The present investigation utilized a previously developed questionnaire tool. The study encompassed a cohort of 732 individuals. Upon inquiry regarding the adverse effects of corticosteroid treatment, the participants predominantly reported weight gain, skin alterations, and fluid retention leading to breathing difficulties, constituting 44.4%, 30.3%, and 27.7% of the responses, respectively. The prevailing adverse effects observed in individuals using corticosteroids were weight gain, alterations in mood, and changes in skin characteristics, which accounted for 38.1%, 25.7%, and 21.8% of reported cases, respectively. Individuals within the age range of 41–50 years and those who are currently not working show a higher propensity for utilizing corticosteroids in comparison to other demographic groups (p < 0.05). The level of general public knowledge about corticosteroids and the side effects connected with them in Saudi Arabia was adequate. Demographic factors, such as age, gender, and education, have an impact on the use of corticosteroids.

Objectives: In the event of cardiac arrest, cardiopulmonary resuscitation (CPR) is an emergency procedure used to maintain the heart and lungs functional simultaneously. The do-not-resuscitate (DNR) order prohibits CPR and is therefore legally required. Despite this, a DNR remains a delicate and contentious issue that places physicians in morally ambiguous situations. This study aimed to assess Saudi citizens’ understanding of DNR orders, prior exposure to them, and preferences for DNR conversations. Methods: This was an online cross-sectional study that was conducted between January and April 2023 and aimed to assess the knowledge regarding DNR orders among Saudi populations. This study adapted a previously developed questionnaire tool by Al Ahmadi et al., which examined the knowledge and attitude toward do-not-resuscitate among patients and their relatives visiting outpatient clinics. Binary logistic regression analysis was the mean knowledge score for the study participants. Results: A total of 920 participants were involved in this study. Almost half of the study participants (49.6%) reported that they had heard of DNR before. The most commonly reported source of their information on DNR was healthcare providers (58.2%). The mean knowledge score of the study participants was 1.9 (1.3) out of 6, which is equal to 31.7% of the total maximum score. This demonstrates the weak level of knowledge about DNR among the general public. Females, divorced, and those who had a post-graduate level of education were more likely to be knowledgeable of DNR compared to others (p < 0.05). Around one-quarter of the study participants showed agreement with DNR. More than half of them (59.5%) believe that physicians should be involved in DNR decision making. Conclusions: Saudi Arabia’s general community has limited knowledge of DNR. It is recommended that healthcare professionals increase patients’ and caregivers’ understanding of this concept. This will improve the planning and the provision of end-of-life care.

The coexistence of primary membranous nephropathy (PMN), immunoglobulin A nephropathy (IgAN), and diabetic nephropathy (DN) in the same patient has been a subject of clinical and pathological investigation, yielding inconclusive results. The limited availability of cases and resource materials has hindered a comprehensive understanding of this phenomenon. We present the case of a 70-year-old Saudi Arabian man diagnosed with type 2 diabetes mellitus and nephrotic syndrome. A kidney biopsy revealed the coexistence of PMN, IgAN, and DN. The patient presented with an unusual and rare combination of PMN, IgAN, and DN. To address his condition, the patient consented to rituximab therapy and planned follow-up with the kidney transplant team. However, before the first dose of rituximab could be administered, the patient experienced severe septic shock secondary to pneumonia, which tragically led to his demise. The simultaneous occurrence of PMN, IgAN, and DN represents a rare and scarcely documented condition. The purpose of this article is to report this exceptional case, emphasizing the significance of further research to deepen the understanding of the underlying pathology behind these concurrent renal disorders. This report aims to shed light on the complexities of managing such complex cases and advancing therapeutic approaches in the future.

Background: Chronic obstructive pulmonary disease (COPD) is a significant burden in Saudi Arabia. Improving the attitudes, awareness, and knowledge of healthcare providers toward advance directives and/or advanced care planning (ACP) can increase the use of advance directives. This study aims to investigate healthcare providers’ knowledge, attitudes, and practices concerning advance directives for COPD patients in Riyadh, Saudi Arabia. Methods: This cross-sectional study was employed to assess the knowledge, attitudes, and practices of healthcare providers towards ACP for COPD patients in Riyadh between June and December 2024. The questionnaire was adapted from previous research. Multiple logistic regression was performed to assess the factors associated with good knowledge and positive attitude. Results: A total of 268 participants were included in the analysis. The total mean of knowledge score was 6.96 ± 2.22 out of 12. A total of 161 participants (60.1%) had a poor knowledge score, and 107 participants (39.9%) had a good knowledge score. The total mean of attitude score was 16.23 ± 23.21 out of 26. A total of 148 participants (55.2%) had a poor attitude score and 120 participants (44.8%) had positive attitude. Participants with over 15 years of experience exhibited significantly higher odds of good knowledge (OR = 6.76, 95% CI = 1.03−44.21, p = 0.04). Participants who lived in the Western region had significantly lower odds of good knowledge (OR = 0.32, 95% CI = 0.14–0.71, p = 0.005). Nurses and respiratory therapists had significantly lower odds of having positive attitude (OR = 0.19, 95% CI = 0.09−0.42, p = 0.0001 and OR = 0.34, 95% CI = 0.16–0.75, p = 0.007, respectively). Participants who lived in the Western region had significantly lower odds of having positive attitude (OR = 0.42, 95% CI = 0.19–0.95, p = 0.005). Conclusions: Healthcare providers in Saudi Arabia demonstrated a moderate level of knowledge of ACP for COPD patients. This was accompanied by a moderately positive attitude towards this practice. Future studies should examine effective educational and professional interventions to enhance ACP practices.

Background: Physical exercise is a potential non-pharmacological therapy for patients with end-stage renal disease (ESRD). Perception of benefits and barriers of exercise among hemodialysis (HD) patients is linked with their exercise behavior. This study aimed to investigate perceptions of exercise benefits and barriers among patients on HD in Saudi Arabia and their associated predictors. Methods: This is a cross-sectional survey study that was conducted in two dialysis centers in Saudi Arabia between May and September 2025. In this research, the Dialysis Patient-perceived Exercise Benefits and Barriers Scale (DPEBBS) was used to examine patients’ perceived benefits and barriers to exercise. Patients’ physical activity status was evaluated using the General Practice Physical Activity Questionnaire (GPPAQ). Multivariate logistic regression analysis was used to define factors influencing positive perception towards physical activities and perceived barriers. Results: This study included 104 patients with ESRD. Most patients expressed positive perceptions regarding the benefits of exercise. The majority agreed or strongly agreed that exercise improves mood (87.5%), prevents muscular atrophy (81.8%), postpones decline in body function (81.7%), and enhances quality of life (83.7%). Regarding barriers to exercise, several concerns were frequently reported by patients. The most prominent barrier was worry about affecting the arteriovenous fistula. Tiredness (70.2%) and muscle fatigue (63.5%) were also commonly cited obstacles. Age was significantly associated with lower odds of perceiving exercise as beneficial (aOR = 0.94; 95%CI:0.91–0.98; p = 0.008). This indicates that older patients were slightly less likely to report a positive perception towards exercise. Having a bachelor’s degree is associated with higher odds of reporting exercise barriers compared with no education (aOR = 16.22, 95%CI:1.29–204.42; p = 0.03). The majority of the patients (78.8%) are classified as physically inactive. Conclusions: This study revealed that most patients on HD in Saudi Arabia have positive perceptions regarding the benefits of exercise. Nevertheless, several barriers were also reported by these patients, with tiredness, worry about affecting the arteriovenous fistula, body pain, and muscle fatigue being the most reported barriers. Further studies are necessary to investigate the relationship between a positive perception of exercise benefits and exercise engagement.

The health-related quality of life (HRQoL) for hemodialysis (HD) patients is typically lower than that of kidney transplant patients. Considering that HRQoL is significant for the treatment and well-being of HD patients, this study aimed to evaluate HRQoL among patients undergoing HD in Saudi Arabia. This is a cross-sectional study that was conducted at Dr Sulaiman Al-Habib Hospital in Riyadh, Saudi Arabia, between June and October 2025. Multivariable logistic regression analysis was performed to examine factors associated with physical and mental health outcomes. This study included 93 HD patients. Males had significantly higher PCS (65.72 ± 29.44) and MCS (72.01 ± 23.70) compared to females (PCS: 45.31 ± 29.75; MCS: 56.17 ± 27.18; P < .001). Educational level significantly differed with MCS ( P = .02), with high school graduates and postgraduate degree holders having higher MCS scores. Employment status was also differed in both PCS ( P < .001) and MCS ( P = .02). Higher itching in the past 24 hours was associated with lower odds of both PCS (adjusted odds ratio (aOR) = 0.76, 95% confidence intervals [CI]: 0.61–0.96, P = .018) and MCS (aOR = 0.64, 95% CI: 0.48–0.85, P = .002). for mental health, being Saudi national (aOR = 0.05, 95% CI: 0.00–0.98, P = .048), having a high school education (aOR = 17.74, 95% CI: 1.99–158.18, P = .010), being a student (aOR = 0.01, 95% CI: 0.00–0.55, P = .024), spending 1 to 5 years (aOR = 0.18, 95% CI: 0.03–1.00, P = .050), were all associated with higher MCS scores. The current study revealed that males had significantly higher PCS and MCS than females. Hence, considering these findings is essential to developing efficacious targeted interventions to improve HRQoL among patients on HD, particularly those with lower PCS and/or MCS scores. Further studies are required to explain differences in PCS and/or MCS scores among certain patients’ demographic groups.