Research Interest: 1. Host-guest complexes (macrocycles) (supramolecular chemistry). Calixarenes are consider the third generation of host molecules (supramolecular chemistry) following the crown ether and cyclodextrin. They are easily synthesized by the condensation reactions of phenols with aldehydes. The aim of this study, is to use a new approach for the efficient separation of specific classes of secondary metabolites extracted from selected medicinal plants by calixarenes-based macrocycles. The extraction will be based on host-guest interactions between the Calixarene receptors and natural compounds or biomolecules present in the plant extract. Furthermore, characterization of the new model system of macrocycles and the biological activity will be investigated. 2. Nanoparticles (Green Technology) & Nanotechnology (Nanoliposomes): Formation of new models of nanoliposomes and Nanoparticles. Interaction of nanoliposomes with blood cells and body tissues, and assessment for antiproliferative activity against different cancer cell lines, and other diseases especially Covid-19. 3. Enzymological Studies: Extraction, Isolation, purification, enzyme kinetics, enzyme inhibition, enzyme immobilization, effects of heavy metals on antioxidant enzymes. 4. Metabolomics. 5. Phyto-Biochemical Studies: Medicinal plants, Bioactive compound, Antioxidant activity, flavonoids content, polyphenolic content, reducing power, antihemolytic activity, antibacterial activity, antifungal acti