In the Mediterranean region, the expansion of greenhouse horticulture has enabled the year-round supply of fresh vegetables. Compared to open field horticulture, this farming method can generate higher returns for farmers. However, it is often associated with significant environmental pressures. This research aims to pinpoint important opportunities for improvement of the environmental and economic performance of greenhouse farming in the Mediterranean region by showing the life cycle’s environmental and economic impacts and by highlighting life cycle hotspots. This is achieved through the combined application of life cycle assessment and life cycle costing to four case studies (commercial greenhouses) spanning the Mediterranean Basin (Italy, Spain, Tunisia, and Turkey). The case study findings highlight the following environmental hotspots and related impacts: (i) fertigation management can generate up to 11,283 m³/ha/year of water use impact; (ii) fertilizer leaching can generate up to 27 kg of N eq marine eutrophication impact; and (iii) crop protection treatments can generate up to 130,037 kg 1,4-DCB of terrestrial ecotoxicity impact. The large use of plastic materials (greenhouse and fertigation infrastructures) is an additional critical aspect due to manufacturing and disposal, contributing to eutrophication impact categories. Economic hotspots are related to greenhouse management (up to 35% total costs of production) and hired labor (up to 40% total costs of production). The lessons learnt from these case studies offer valuable insights into the sustainability challenges of greenhouse horticulture across the Mediterranean region. The hotspot analysis points to the need for targeted interventions to mitigate the most critical impacts while ensuring economic viability. This study enriches scientific understanding by examining different production and socioeconomic contexts, offering crucial insights for the advancement of sustainable practices in greenhouse agriculture such as the use of decision support systems to optimize input use.

Agriculture 4.0 represents a huge opportunity for the transformation of agrifood sectors. However, its adoption (and diffusion) in real-world farming contexts faces multiple challenges. This study focuses on greenhouse farming within the Mediterranean basin. It aims to assess the needs of actors involved in the uptake of Agriculture 4.0 and define enabling conditions to support achieving these needs, focusing on the introduction of an innovative decision support system in real-world greenhouses for tomato production. A qualitative and comparative approach is implemented, using participatory data collection methods with cross-disciplinary experts from four case studies across the Mediterranean Basin. Data are collected through one-to-one open discussions, supported using context and SWOT analyses to stimulate reflection and recall. The findings highlight the need to improve digital literacy among farmers and advisors, build trust through tailored education conditions and mentorship, and support young farmers with financial incentives and training. Market dynamics are relevant as well, pinpointing the need for stronger product images and increasing consumer awareness through certification and labelling. Great interest and technology potential emerges from the possibility to enable (partial) remote work thereby benefiting a work-life balance. Simplifying bureaucratic processes and enhancing policy support for cooperation and farmer unions are also essential for encouraging farmers to adopt digital technology.