Photodynamic therapy (PDT) has received increased attention since the regulatory approvals have been granted to several photosensitizing drugs and light applicators worldwide. Much progress has been seen in basic sciences and clinical photodynamics in recent years. This review will focus on new developments of clinical investigation and discuss the usefulness of various forms of PDT techniques for curative or palliative treatment of malignant and non-malignant diseases.

Photodynamic therapy (PDT) involves the administration of photosensitizer followed by local illumination with visible light of specific wavelength(s). In the presence of oxygen molecules, the light illumination of photosensitizer can lead to a series of photochemical reactions and consequently the generation of cytotoxic species. The quantity and location of PDT-induced cytotoxic species determine the nature and consequence of PDT. Much progress has been seen in both basic research and clinical application in recent years. Although the majority of approved PDT clinical protocols have primarily been used for the treatment of superficial lesions of both malignant and non-malignant diseases, interstitial PDT for the ablation of deep-seated solid tumors are now being investigated worldwide. The complexity of the geometry and non-homogeneity of solid tumor pose a great challenge on the implementation of minimally invasive interstitial PDT and the estimation of PDT dosimetry. This review will discuss the recent progress and technical challenges of various forms of interstitial PDT for the treatment of parenchymal and/or stromal tissues of solid tumors.

Photodynamic therapy (PDT) is a therapeutic modality that depends on the interaction of light, photosensitizers, and oxygen. The photon absorption and energy transfer process can lead to the Type II photochemical reaction of the photosensitizer and the production of singlet oxygen (¹O₂), which strongly oxidizes and reacts with biomolecules, ultimately causing oxidative damage to the target cells. Therefore, ¹O₂ is regarded as the key photocytotoxic species accountable for the initial photodynamic reactions for Type II photosensitizers. This article will provide a comprehensive review of ¹O₂ properties, ¹O₂ production, and ¹O₂ detection in the PDT process. The available ¹O₂ data of regulatory-approved photosensitizing drugs will also be discussed.

OBJECTIVE. The aim of our study was to evaluate CT scanning protocols to determine how best to minimize patient exposure to ionizing radiation while maintaining sufficient image quality to detect pulmonary diseases. SUBJECT AND METHODS. The CT dose index (CTDI) was determined by scanning an acrylic phantom at various tube current–time products (7.5–115 mAs). Image quality was evaluated by comparing the homogeneity and noise level of CT scans obtained in the acrylic phantom with those obtained in a water-equivalent phantom. The CT scans obtained at various milliampere-second settings in patients with nodules or diffuse opacifications were assessed. The relationships between the CTDI and the image quality of the CT scans (noise level and artifacts) were established. RESULTS. The reduction of a conventional tube current–time product (115 mAs) by 65%, 78%, or 93.5% can decrease the CTDI by 60%, 70%, or 85%, respectively. In correlating the image quality of each CT scan to the milliampere-second settings used to obtain it, we found that homogeneity decreased as milliampere-second settings decreased, whereas the noise level increased as milliampere-second settings decreased. For both 8- and 3-mm slice thicknesses, the homogeneity of CT scans acquired at 7.5 mAs or greater was within the acceptable range (< 4 H). However, the noise level of CT scans remained within the acceptable range (< 0.35%) when 25 mAs or greater was used. The evaluation of the image quality of the patients' CT scans indicated no statistical significance in image quality rating between the scans obtained at 25 mAs and those obtained at 115 mAs (p > 0.01). CONCLUSION. Low-dose (i.e., 40 or 25 mAs) helical chest CT produced satisfactory image quality and reduced the CTDI, thereby maximally protecting patients from radiation exposure.