Nicolas Hucher

Dr. Nicolas Hucher

orcid

Research Focus & Metrics

Academic Career Length

13Years (2014-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
29 January 2020 in International Journal of Cosmetic Science
Verified
Journal Article
Closed access
PDF file
DTDaria Terescenco
Daria Terescenco
NHNicolas Hucher
Nicolas Hucher
CPC. Picard
C. Picard
GSGéraldine Savary
Géraldine Savary

1 January 2014 in International Journal of Pharmaceutics
Verified
Journal Article
Closed access
MRManon Rossano
Manon Rossano
NHNicolas Hucher
Nicolas Hucher
CPCéline Picard
Céline Picard
DCDaniel Colletta
Daniel Colletta
FFFrank Le Foll
Frank Le Foll
MGMichel Grisel
Michel Grisel

17 August 2021 in International Journal of Cosmetic Science
Verified
Journal Article
Closed access
PDF file
DTDaria Terescenco
Daria Terescenco
LBLalia Hadj Benali
Lalia Hadj Benali
FCFabien Canivet
Fabien Canivet
MGMaud Benoit le Gelebart
Maud Benoit le Gelebart
NHNicolas Hucher
Nicolas Hucher
CPCéline Picard
Céline Picard

25 January 2019 in Chemical Research in Toxicology
Verified
Journal Article
Closed access
FEFlorine Eudier
Florine Eudier
NHNicolas Hucher
Nicolas Hucher
CPCéline Picard
Céline Picard
GSGéraldine Savary
Géraldine Savary
MGMichel Grisel
Michel Grisel

16 April 2024 in International Journal of Pharmaceutics
Verified
Journal Article
Open access
DTDaria Terescenco
Daria Terescenco
GSGéraldine Savary
Géraldine Savary
CPCeline Picard
Celine Picard
NHNicolas Hucher
Nicolas Hucher
The interest in Pickering emulsions is based on the possibility of replacing classical emulsifiers with solid particles. These emulsions are very attractive in the pharmaceutical field for their stability virtues and as a vehicle to deliver active ingredients. The study aimed to analyze the properties of the residual film of the Pickering emulsions on the human skin compared to conventional systems. For this project, three types of solid particles were used: titanium dioxide, zinc oxide and silicon dioxide. All of them are capable of stabilizing the oil/water interface and thus forming totally emulsified systems. To create an emulsion of reference, a classical surfactant was used as an excipient. Complementary systems containing both particles and the emulsifier were also analyzed. Then, a combined approach between physicochemical and biometrological in vivo analysis was employed. The study proved that Pickering emulsions stabilized by the metal oxides were distinct from the reference emulsion in terms of droplet sizes and organization, rheological and textural responses. Consequently, it impacted the properties of the residual film once the product was applied to the skin. The particle-stabilized emulsions formed a hydrophobic film counter to conventional excipients. Also, the Friction parameter (or the roughness of the film) was directly linked to the quantity of the particles used in the formulation and their perception on the skin surface. The use of the particles blurs the glossy effect of the oil phase. Finally, it was observed that the appearance of the residual film was impacted by the type of the particle, namely TiO 2 and ZnO particles.