Protected cultivation, as a core model of modern agriculture, holds a crucial strategic position in alleviating the shortage of arable land resources and increasing farmers’ income. However, due to the closed environment of protected cultivation, suitable temperature and humidity conditions for pathogen reproduction, serious continuous cropping obstacles, disease transmission easily caused by irrigation, and the lack of natural ultraviolet inhibition and crop rotation conditions, soil-borne pathogens accumulate year by year, resulting in early onset, rapid spread, and great difficulty in control. Traditional pesticide formulations often have limitations such as environmental hazards, low utilization rate, unstable active ingredients, excessive use, and short persistence in the control process. In recent years, pesticide slow-release carriers developed based on nanotechnology to regulate the slow-release behavior of pesticide active ingredients have shown great potential in improving pesticide efficacy and safety. This article reviews several commonly used materials for mineral carriers, metal oxide carriers, organic polymer carriers, and organic–inorganic hybrid carriers. With their high specific surface area, high drug loading rate, environmental friendliness, and stimulus-responsive properties, these materials can significantly improve the effective utilization rate of pesticides, extend the persistence period, and enhance targeting, thus providing strong technical support for solving the problem of soil-borne disease control in protected cultivation and promoting the green and sustainable development of protected cultivation.