Importance: Burnout is common among occupational therapy professionals and associated with poor health and well-being, absenteeism, turnover, and exit from the profession. This study identified specific job titles, job characteristics, and resources related to burnout. Objective: To identify specific aspects of occupational therapy jobs related to burnout and to investigate job crafting as one approach for reducing burnout. Design: Cross-sectional survey. Participants: Four hundred occupational therapy professionals from 45 states across the United States. Outcomes and Measures: This study investigated the relative importance of job demands (e.g., workload, emotional labor, role ambiguity), job resources (e.g., professional identity, autonomy, perceived support), and burnout and examined job crafting as a strategy for reducing burnout. Results: Burnout varied across occupational therapy positions and practice areas and was most strongly associated with excessive workload. Occupational therapy professionals who engaged in job crafting reported less burnout. Several positive job resources, including meaningful work, job involvement, and perceived organizational support, were also associated with job crafting. Conclusions and Relevance: This study identified specific occupational therapy roles, settings, and job characteristics related to burnout and job crafting behaviors that may help reduce burnout. Plain-Language Summary: Burnout is common among occupational therapy professionals and is associated with poor health and well-being, absenteeism, turnover, and people leaving the profession. This study identifies occupational therapy positions, practice areas, and work conditions at most risk for burnout and highlights job resources that can prevent and mitigate burnout. The study found that burnout varied across occupational therapy positions and practice areas and was most strongly associated with excessive workload. Recommendations to address burnout include engaging in job crafting, optimizing job demands and resources, and fostering meaningful work to reduce burnout.