Moon Kyung Joo, Chan Hyuk Park, Joon Sung Kim, Jae Myung Park, Ji Yong Ahn, Bong Eun Lee, Jeong Hoon Lee, Hyo-Joon Yang, Yu Kyung Cho, Chang Seok Bang, Beom Jin Kim, Hye-Kyung Jung, Byung-Wook Kim, and Yong Chan Lee, Korean College of Helicobacter and Upper Gastrointestinal Research. Gut and Liver 2020;14:707-26. https://doi.org/10.5009/gnl20246

Background: Bismuth‐based quadruple therapy (BQT) is recommended as the first‐line empirical therapy for Helicobacter pylori eradication as it is not associated with resistance. However, few studies have investigated the use of potassium‐competitive acid blockers for BQT.Aim: To investigate the efficacy and safety profiles of tegoprazan‐based BQT (TBMT) versus lansoprazole‐based BQT (LBMT) for H. pylori eradication.Methods: We included patients older than 18 with an H. pylori infection without a history of H. pylori eradication who visited four university‐affiliated hospitals between March 2020 and December 2021. H. pylori infection was diagnosed using a rapid urease test or Giemsa staining. Patients were randomly assigned to the TBMT or LBMT group.Results: 217 subjects were randomly allocated to receive either TBMT (n = 108) or LBMT (n = 109) therapy. Intention‐to‐treat (ITT) eradication rates of TBMT and LBMT were 80.0% and 77.4% (95% confidence interval [CI]: −8.4 to 13.7, p = 0.0124), respectively. Corresponding modified ITT rates were 90.3% and 84.5% (95% CI: −3.6 to 15.2, p = 0.0005), respectively. Per‐protocol (PP) eradication rates of TBMT and LBMT were 90.2% and 82.4% (95% CI: −2.5 to 18.2, p = 0.0003), respectively. There was no significant difference in the rate of adverse events between the TBMT and LBMT groups (39.1% vs. 43.4%, p = 0.5211). TBMT showed higher eradication rates than that of LBMT in ITT, m‐ITT, and PP analysis.Conclusion: TBMT showed a noninferior eradication rate and similar adverse events to LBMT as a first‐line eradication regimen. Our results suggest that tegoprazan might be substituted for proton pump inhibitors in H. pylori eradication regimens.

Joon Sung Kim, Byung-Wook Kim, Do Hoon Kim, Chan Hyuk Park, Hyuk Lee, Moon Kyung Joo, Da Hyun Jung, Jun- Won Chung, Hyuk Soon Choi, Gwang Ho Baik, Jeong Hoon Lee, Kyo Young Song, and Saebeom Hur, The Korean Society of Gastroenterology, Korean College of Helicobacter and Upper Gastrointestinal Research, Korean Society of Gastrointestinal Endoscopy, The Korean Gastric Cancer Association, Korean Society of Interventional Radiology. Gut and Liver 2020;14:560-70. https://doi.org/10.5009/gnl20154

Joon Sung Kim, Seung In Seo, Sun Hyung Kang, Sang Kil Lee, Ah Rong Kim, Hyun Wook Park, Bong Tae Kim, and Geun Seog Song. J Neurogastroenterol Motil 2023;29:58-64. https://doi.org/10.5056/jnm22104