The complex global context, including globalization, rapid urbanization, and climate change, poses significant challenges to urban stability and development. Balancing urban land use efficiency and resilience is crucial for sustainable progress. Focusing on the vulnerable Yellow River Basin (YRB), this study examines the interplay between urban resilience and land use efficiency. Panel data from 2013 to 2020 for 54 cities in the YRB were used, it quantifies the Coupling Coordination Degree of Urban Resilience and Urban Land Use Efficiency (CCDUU), explores its spatiotemporal evolution and influencing factors. Key findings include: The CCDUU exhibits a sustained and discernible growth trend. Notably, CCDUU is higher in downstream areas in comparison to the middle reaches, reaching its lowest point in the upstream areas; however, the increase in CCDUU in the upstream areas surpasses that observed in other regions. Concurrently, regional disparities in CCDUU are diminishing. Despite the presence of a notable positive spatial correlation in CCDUU within the YRB, the strength of this spatial association is not sufficiently robust. Of paramount importance factor is the role of regional innovation, which significantly influences the enhancement of CCDUU. Following closely is the degree of openness, whereas the positive effects of government support and population density are concentrated predominantly in the upper YRB region. In contrast, urban-rural disparity exerts an adverse impact on CCDUU in most regions. Policy recommendations for enhancing CCDUU in YRB cities include strengthening government support and planning control, particularly in upstream regions, to achieve efficient resource utilization and environmental protection. Implementing population density management policies, encouraging rational movement, and promoting population migration to upstream areas can alleviate pressure in downstream cities. Enhancing openness, attracting foreign investment, and promoting innovation and industrial upgrading will drive economic structural upgrades and improve CCDUU.