Chung K. Chu

Prof. Dr. Chung K. Chu


Research Focus & Metrics

Academic Career Length

32Years (1995-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 September 2008 in Journal of Fluorine Chemistry
Verified
Journal Article
Closed access
PLPeng Liu
Peng Liu
ASAshoke Sharon
Ashoke Sharon
CCChung K. Chu
Chung K. Chu

1 October 2002 in Current Topics in Medicinal Chemistry
Verified
Journal Article
Closed access
PDF file
GGGiuseppe Gumina
Giuseppe Gumina
YCYouhoon Chong
Youhoon Chong
HCHyunah Choo
Hyunah Choo
GSGyu-Yong Song
Gyu-Yong Song
CCChung K. Chu
Chung K. Chu
Drug discovery for antiviral chemotherapy has provided the effective treatment of numerous viral diseases. Among antiviral agents used in therapy, nucleoside analogues have been particularly useful. In fact, almost twenty nucleosides are currently used in antiviral therapy, seven of which are for the treatment of HIV infection. In the search for new and effective agents within this class, the focus has recently expanded on L-analogues, characterized by opposite configuration compared to the natural D-nucleosides. The interest in L-nucleosides has risen since the discovery of 3TC, one of the most important drugs used in the treatment of AIDS and hepatitis B infection. This review will discuss the latest advances in L-nucleosides as antiviral agents with a particular focus on the synthesis and molecular mechanism as well as metabolic differences between L- and D-nucleosides.

13 September 2000 in Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
CCChung K. Chu
Chung K. Chu
LMLi Ma
Li Ma
SOSureyya Olgen
Sureyya Olgen
CPClaire Pierra
Claire Pierra
JDJinfa Du
Jinfa Du
RSRaymond F. Schinazi
Raymond F. Schinazi

1 August 2001 in FEMS Microbiology Letters
Verified
Journal Article
Open access
PDF file
GGGiuseppe Gumina
Giuseppe Gumina
GSGyu-Yong Song
Gyu-Yong Song
CCChung K. Chu
Chung K. Chu
Nucleoside analogues have been the cornerstone of antiviral therapy over the past thirty years and, currently, 16 commonly used antiviral drugs belon

1 October 2006 in Antiviral Chemistry and Chemotherapy
Verified
Journal Article
Open access
PDF file
CCChung K. Chu
Chung K. Chu
SGSrinivas Gadthula
Srinivas Gadthula
XCXin Chen
Xin Chen
HCHyunah Choo
Hyunah Choo
SOSureyya Olgen
Sureyya Olgen
RSRobert W Sidwell
Robert W Sidwell
The recent outbreak of severe acute respiratory syndrome (SARS), which is an acute respiratory illness, is caused by newly discovered SARS coronavirus (SARS-CoV). Herein we describe the antiviral activity of several classes of nucleoside analogues evaluated against SARS-CoV in Vero 76 cells, some of which exhibited moderate activity.

8 February 2006 in Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
HCHyunah Choo
Hyunah Choo
XCXin Chen
Xin Chen
VYVikas Yadav
Vikas Yadav
JWJianing Wang
Jianing Wang
RSRaymond F. Schinazi
Raymond F. Schinazi
CCChung K. Chu
Chung K. Chu