Uveal melanoma arises from melanocytes within the choroid of the eye, has an incidence of 1500 cases per year in the United States, and is biologically distinct from cutaneous melanoma.^1,2 Despite enucleation or definitive radiotherapy of the primary lesion, metastases develop in 50% of patients and outcomes are subsequently poor, with a median survival of less than 12 months.^3-5 Although improved outcomes have been achieved in patients with advanced cutaneous melanoma, no effective therapy has been identified for those with metastatic uveal melanoma.

A panel of experts reached consensus on recommendations on when to assess oncologic outcomes per patient, per session, and per tumor; definitions of starting and ending times; definitions of surviv... There is currently no consensus regarding preferred clinical outcome measures following image-guided tumor ablation or clear definitions of oncologic end points. This consensus document proposes st...

The use of a split-dose technique for percutaneous ablation with fluorine 18 fluorodeoxyglucose (FDG) PET guidance facilitates targeting of FDG-avid lesions and may provide confirmation of treatment effectiveness. PurposeTo describe a split-dose technique for fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT)-guided ablation that permits both target localization and evaluation of treatment effectiveness.Materials and MethodsInstitutional review board approved the study with a waiver of consent. From July to December 2011, 23 patients (13 women, 10 men; mean age, 59 years; range, 35–87 years) with 29 FDG-avid tumors (median size, 1.4 cm; range, 0.6–4.4 cm) were targeted for ablation. The location of the lesion was the liver (n = 23), lung (n = 4), adrenal gland (n = 1), and thigh (n = 1). Radiofrequency ablation was performed in 17 lesions; microwave ablation, in six; irreversible electroporation, in five; and cryoablation, in one. The pathologic condition of the tumor was metastatic colorectal adenocarcinoma in 18 lesions, primary hepatocellular carcinoma in one lesion, and a variety of metastatic tumors in the remaining 10 lesions. A total of 4 mCi (148 MBq) of FDG was...