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Dr. Jianzhong Huang
Department of Basic Medicine, Fuzhou Medical College, Fuzhou, Jiangxi, China
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8Years (2019-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications5 April 2019 in Frontiers in Plant Science
Journal Article
ZLZhaowu Li
Zhaowu Li
JHJianzhong Huang
Jianzhong HuangZWZhangying Wang
Zhangying Wang
FMFen Meng
Fen Meng
SZSiyuan Zhang
Siyuan Zhang
ZGZhiyong Gao
Zhiyong Gao +2
The nucleotide-binding domain leucine-rich repeat (NLR) immune receptors play important roles in innate plant immunity. The activation of NLRs is specifically induced by their cognate effectors released from pathogens. Autoactive NLRs are expected to confer broad-spectrum resistance because they do not need cognate effectors to activate their immune responses. In this study, we demonstrated that the NLR genes RPS2 and RPM1(D505V) from Arabidopsis were autoactive in Oryza sativa and conferred broad-spectrum resistance to fungal pathogen Magnaporthe oryzae, bacterial pathogen Xanthomonas oryzae pv. oryzae (Xoo), and pest brown planthopper (BPH, Nilaparvata lugens Stål). These results revealed that interfamily transfer of dicot NLRs to monocot species could be functional. The transgenic plants displayed early and strong induction of reactive oxygen species (ROS), callose deposition, and expression of defense-related genes after challenged with M. oryzae. The transcriptome analysis showed that the expressions of some defense-related genes were primed to adapt the transformed autoactive NLRs in the transgenic plants. This study indicates that autoactive NLRs are a promising resource for breeding crops with broad-spectrum resistance and provides new insights for engineering disease resistance.
18 January 2019 in Frontiers in Plant Science
Journal Article
XYXin Yuan
Xin Yuan
ZWZhangying Wang
Zhangying Wang
JHJianzhong Huang
Jianzhong HuangHXHua Xuan
Hua Xuan
ZGZhiyong Gao
Zhiyong GaoRPM1 is a plant immune receptor that specially recognizes pathogen-released effectors to activate effector-triggered immunity (ETI) in Arabidopsis thaliana. RPM1 triggers ETI and hypersensitive response (HR) for disease resistance. Previous reports indicated that Phospholipase D (PLD) positively regulated RPM1-mediated HR. However, single, double, and triple pld knock-out mutants of 12 members of the PLD family in A. thaliana did not show suppressed RPM1-mediated HR, indicating the functional redundancy among PLD members. In this study, we revealed that PLD could negatively regulate the function of RPM1. We found that RPM1 interacted with PLDδ, but did not interact with PLDβ1, PLDβ2, and PLDγ3. Overexpression of PLDδ conducted to a reduction of protein level and corresponding activity of RPM1. We found that abscisic acid (ABA) reduced the protein level of RPM1, and the ABA-induced RPM1 reduction required PLD activity and PLD-derived phosphatidic acid (PA). Our study shows that PLD plays both negative and positive roles regulating the protein level and activity of RPM1 during stress responses in plants. PLD proteins are regulating points to integrate the abiotic and biotic responses of plants.
1 January 2021 in Biochemical and Biophysical Research Communications
Journal Article
JHJianzhong Huang
Jianzhong HuangXWXiaoqiu Wu
Xiaoqiu Wu
KSKaiting Sun
Kaiting Sun
ZGZhiyong Gao
Zhiyong Gao1 November 2021 in Biochemical and Biophysical Research Communications
Journal Article
1 May 2021 in Biochemical and Biophysical Research Communications
Journal Article
1 December 2021 in Biochemical and Biophysical Research Communications
Journal Article
About Me
Jianzhong Huang, a lecturer, obtained his Ph.D. degree in Molecular Genetics from the State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University in 2021. In the same year, he joined the department of basic medicine, Fuzhou Medical College of Nanchang University (currently Fuzhou Medical College). His research focuses on the activation mechanisms of plant immune receptor proteins, particularly nucleotide-binding leucine-rich repeat receptors (NLRs). His major research systems include Arabidopsis thaliana and Nicotiana benthamiana. Since joining Fuzhou Medical College, he has published several SCIE-indexed research articles in journals including Gene, Genes, Life, Plants and Biochemical and Biophysical Research Communications (BBRC), along with more than ten other academic publications. He has served as the principal investigator for several completed research projects at the university, municipal, departmental, and provincial levels, and has participated in two national-level research projects. Currently, he is leading a youth project supported by the Jiangxi Provincial Natural Science Foundation and a Science and Technology Research Project supported by the Jiangxi Provincial Department of Education.