The scouring effect is widely acknowledged as a primary contributor to the weakening in the bearing performance of offshore piles; it often results in asymmetric scour patterns around the pile. To meticulously examine the impact of three-dimensional asymmetric local scour on the lateral bearing performance of a single pile, the Boussinesq solution is employed to determine the effective stress within the soil encompassing the pile, considering the presence of a three-dimensional asymmetric local scour hole. Utilizing the strain wedge model, the calculation method for the lateral bearing performance of a single pile under the condition of three-dimensional asymmetric local scour is established. The validity of this approach is established, and parameter analysis unveils the effect of varying sizes of three-dimensional asymmetric scour holes on the mechanical properties and displacement performance of a single pile. The analysis reveals that, as scouring dimensions around the pile escalate, the impact of scouring on single-pile lateral displacement and internal forces intensifies, leading to a decrease in the lateral bearing performance of a single pile. At a constant scour depth, the bottom area of the upstream scour hole significantly influences the displacement performance of a single pile. When the bottom length S_wb1 of the upstream scour hole grows by 1 time, 4 times, and 8 times, the lateral displacement of a single pile at a buried depth of 6 m is augmented by approximately 0.41%, 1.65%, and 2.06%, respectively. The simplified model obtained via the modified strain wedge model and Boussinesq solution can provide a theoretical basis for the preliminary design of a single pile under asymmetric scour hole conditions.