Several models for mortality prediction have been constructed for critically ill patients with haematological malignancies in recent years. These models have proven to be equally or more accurate in predicting hospital mortality in patients with haematological malignancies than ICU severity of illness scores such as the APACHE II or SAPS II 1. The objective of this study is to compare the accuracy of predicting hospital mortality in patients with haematological malignancies admitted to the ICU between models based on multiple logistic regression (MLR) and support vector machine (SVM) based models.

The advent of softwarized networks has enabled the deployment of chains of virtual network and service components on computational resources from the cloud up to the edge, creating a continuum of virtual resources. The next generation of low latency applications (e.g., Virtual Reality (VR), autonomous cars) adds even more stringent requirements to the infrastructure, calling for considerable advancements towards cloud-native micro-service-based architectures. This article presents a comprehensive survey on ongoing research aiming to effectively support low latency services throughout their execution lifetime in next-generation networks. The current state-of-the-art is critically reviewed to identify the most promising trends that will strongly impact the full applicability and high performance of low latency services. This article proposes a taxonomy as well as specific evaluation criteria to classify research across different domains addressing low latency service delivery. Current architectural paradigms such as Multi-access Edge Computing (MEC) and Fog Computing (FC) alongside novel trends on communication networks are discussed. Among these, the integration of Machine Learning (ML) and Artificial intelligence (AI) is introduced as a key research field in current literature towards autonomous network management. A discussion on open challenges and future research directions on low-latency service delivery leads to the conclusion, offering lessons learned and prospects on emerging use cases such as Extended Reality (XR), in which novel trends will play a major role.

Autism Spectrum Disorder (ASD) is characterized by social interaction difficulties and communication difficulties. Moreover, children with ASD often suffer from other co-morbidities, such as anxiety and depression. Finding appropriate treatment can be difficult as symptoms of ASD and co-morbidities often overlap. Due to these challenges, parents of children with ASD often suffer from higher levels of stress. This research aims to investigate the feasibility of empowering children with ASD and their parents through the use of a serious game to reduce stress and anxiety and a supporting parent application. The New Horizon game and the SpaceControl application were developed together with therapists and according to guidelines for e-health patient empowerment. The game incorporates two mini-games with relaxation techniques. The performance of the game was analyzed and usability studies with three families were conducted. Parents and children were asked to fill in the Spence’s Children Anxiety Scale (SCAS) and Spence Children Anxiety Scale-Parents (SCAS-P) anxiety scale. The game shows potential for stress and anxiety reduction in children with ASD.

An intrusion detection system (IDS), traditionally an example of an effective security monitoring system, is facing significant challenges due to the ongoing digitization of our modern society. The growing number and variety of connected devices are not only causing a continuous emergence of new threats that are not recognized by existing systems, but the amount of data to be monitored is also exceeding the capabilities of a single system. This raises the need for a scalable IDS capable of detecting unknown, zero-day, attacks. In this paper, a novel multi-stage approach for hierarchical intrusion detection is proposed. The proposed approach is validated on the public benchmark datasets, CIC-IDS-2017 and CSE-CIC-IDS-2018. Results demonstrate that our proposed approach besides effective and robust zero-day detection, outperforms both the baseline and existing approaches, achieving high classification performance, up to 96% balanced accuracy. Additionally, the proposed approach is easily adaptable without any retraining and takes advantage of n-tier deployments to reduce bandwidth and computational requirements while preserving privacy constraints. The best-performing models with a balanced set of thresholds correctly classified 87% or 41 out of 47 zero-day attacks, while reducing the bandwidth requirements up to 69%.

Fog computing extends the cloud computing paradigm by placing resources close to the edges of the network to deal with the upcoming growth of connected devices. Smart city applications, such as health monitoring and predictive maintenance, will introduce a new set of stringent requirements, such as low latency, since resources can be requested on-demand simultaneously by multiple devices at different locations. It is then necessary to adapt existing network technologies to future needs and design new architectural concepts to help meet these strict requirements. This article proposes a fog computing framework enabling autonomous management and orchestration functionalities in 5G-enabled smart cities. Our approach follows the guidelines of the European Telecommunications Standards Institute (ETSI) NFV MANO architecture extending it with additional software components. The contribution of our work is its fully-integrated fog node management system alongside the foreseen application layer Peer-to-Peer (P2P) fog protocol based on the Open Shortest Path First (OSPF) routing protocol for the exchange of application service provisioning information between fog nodes. Evaluations of an anomaly detection use case based on an air monitoring application are presented. Our results show that the proposed framework achieves a substantial reduction in network bandwidth usage and in latency when compared to centralized cloud solutions.

The Internet-of-Things (IoT) and Smart Cities continue to expand at enormous rates. Centralized Cloud architectures cannot sustain the requirements imposed by IoT services. Enormous traffic demands and low latency constraints are among the strictest requirements, making cloud solutions impractical. As an answer, Fog Computing has been introduced to tackle this trend. However, only theoretical foundations have been established and the acceptance of its concepts is still in its early stages. Intelligent allocation decisions would provide proper resource provisioning in Fog environments. In this article, a Fog architecture based on Kubernetes, an open source container orchestration platform, is proposed to solve this challenge. Additionally, a network-aware scheduling approach for container-based applications in Smart City deployments has been implemented as an extension to the default scheduling mechanism available in Kubernetes. Last but not least, an optimization formulation for the IoT service problem has been validated as a container-based application in Kubernetes showing the full applicability of theoretical approaches in practical service deployments. Evaluations have been performed to compare the proposed approaches with the Kubernetes standard scheduling feature. Results show that the proposed approaches achieve reductions of 70% in terms of network latency when compared to the default scheduling mechanism.