Manganese-based nanomaterials have seen rapid development in chemodynamic therapy and T ₁ -enhanced MRI over the past five years, holding promising prospects in various combined applications.

Cancer is a significant global public health issue with increasing morbidity and mortality rates. To address this challenge, novel drug carriers such as nano-materials, liposomes, hydrogels, fibers, and microspheres have been extensively researched and utilized in oncology. Among them, polymer microspheres are gaining popularity due to their ease of preparation, excellent performance, biocompatibility, and drug-release capabilities. This paper categorizes commonly used materials for polymer microsphere preparation, summarizes various preparation methods (emulsification, phase separation, spray drying, electrospray, microfluidics, and membrane emulsification), and reviews the applications of polymer microspheres in cancer diagnosis, therapy, and postoperative care. The current status and future development directions of polymer microspheres in cancer treatment are analyzed, highlighting their importance and potential for improving patient outcomes.

Vitamin C (VC), also known as ascorbic acid, plays a crucial role as a water-soluble nutrient within the human body, contributing to a variety of metabolic processes. Research findings suggest that increased doses of VC demonstrate potential anti-tumor capabilities. This review delves into the mechanisms of VC absorption and its implications for cancer management. Building upon these foundational insights, we explore modern delivery systems for VC, evaluating its use in diverse cancer treatment methods. These include starvation therapy, chemodynamic therapy (CDT), photothermal/photodynamic therapy (PTT/PDT), electrothermal therapy, immunotherapy, cellular reprogramming, chemotherapy, radiotherapy, and various combination therapies.

Ferroptosis, characterized by iron accumulation and lipid peroxidation, has demonstrated anti-tumor properties in multiple malignancies. Long non-coding RNAs play a crucial role in the tumorigenesis and progression of cervical squamous cell cancer; however, the mechanisms underlying the actions of many lncRNAs in ferroptosis remain elusive. Here, the expression level of LICN-TMPO-AS1 in CESC was detected using quantitative real-time polymerase chain reaction. Loss- and gain-of-function experiments with TMPO-AS1 were performed using the CCK-8 assay, transwell assays, clone formation assays, and xenograft models. The relationship between TMPO-AS1, Lipocalin 2, and SFPQ were identified and validated by RNA pull-down/mass spectrometry, co-immunoprecipitation, RNA immunoprecipitation (RIP) assay and western blotting. We found that TMPO-AS1 expression was frequently upregulated in CESC tissues and cells and was strongly associated with poor prognosis. TMPO-AS1 decreased the lipid reactive oxygen species, intracellular Fe²⁺, and malondialdehyde content, leading to the inhibition of sulfasalazine- and erastin-induced ferroptosis. Overexpression of TMPO-AS1 weakened the anti-tumor sensitivity to sulfasalazine by inhibiting ferroptosis both in vitro and in vivo. Mechanistically, TMPO-AS1 bound LCN2 and activated LCN2 expression. Targeting LCN2 reduced iron accumulation and ROS generation in Siha cells. Furthermore, LCN2 regulated the expression of solute carrier family 7 member 11 by interacting with the splicing factor proline and glutamine-rich. Our study illustrates that TMPO-AS1 functions as a tumorigenic regulator and may be a promising therapeutic target for CESC patients with high TMPO-AS1 expression.