The inherent second harmonic power pulse in single-phase grid-connected rectifiers leads to a noticeable output voltage ripple and thus results in the degradation of the system. A novel second harmonic suppression control is introduced in this paper to address this issue. The key point of the proposed control lies in the real-time prediction of the phase-shifted full-bridge (PSFB) converter’s desired duty cycle through accurate PSFB converter modeling. By accurately predicting the ideal duty cycle, the proposed control facilitates a significant enhancement in the control loop’s gain specifically at the second harmonic frequency, thereby improving the overall system performance. To validate the theoretical analysis, a series of simulations and experiments were conducted. The results demonstrate the effectiveness of the proposed second harmonic suppression control in mitigating second harmonic output voltage ripple.