Niraj H Tolia

Dr. Niraj H Tolia

orcid

Research Focus & Metrics

Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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30 March 2005 in Nature Structural & Molecular Biology
Verified
Journal Article
Closed access
PDF file
FRFabiola V Rivas
Fabiola V Rivas
NTNiraj H Tolia
Niraj H Tolia
JSJi-Joon Song
Ji-Joon Song
JAJuan P Aragon
Juan P Aragon
JLJidong Liu
Jidong Liu
LJLeemor Joshua-Tor
Leemor Joshua-Tor

1 November 2006 in Cell
Verified
Journal Article
Closed access
EYErbay Yigit
Erbay Yigit
PBPedro J. Batista
Pedro J. Batista
YBYanxia Bei
Yanxia Bei
KPKa Ming Pang
Ka Ming Pang
CCChun-Chieh G. Chen
Chun-Chieh G. Chen
CMCraig C. Mello
Craig C. Mello

16 November 2003 in Nature Structural & Molecular Biology
Verified
Journal Article
Closed access
PDF file
JSJi-Joon Song
Ji-Joon Song
JLJidong Liu
Jidong Liu
NTNiraj H Tolia
Niraj H Tolia
JSJonathan Schneiderman
Jonathan Schneiderman
SSStephanie K Smith
Stephanie K Smith
LJLeemor Joshua-Tor
Leemor Joshua-Tor

15 December 2006 in Nature Chemical Biology
Verified
Journal Article
Closed access
PDF file
NTNiraj H Tolia
Niraj H Tolia
LJLeemor Joshua-Tor
Leemor Joshua-Tor

1 July 2005 in Cell
Verified
Journal Article
Closed access
NTNiraj H Tolia
Niraj H Tolia
EEEric J. Enemark
Eric J. Enemark
BSB. Kim Lee Sim
B. Kim Lee Sim
LJLeemor Joshua-Tor
Leemor Joshua-Tor

13 May 2021 in npj Vaccines
Verified
Journal Article
Open access
PDF file
BNBrian Nguyen
Brian Nguyen
NTNiraj H Tolia
Niraj H Tolia
Modern vaccine design has sought a minimalization approach, moving to the isolation of antigens from pathogens that invoke a strong neutralizing immune response. This approach has created safer vaccines but may limit vaccine efficacy due to poor immunogenicity. To combat global diseases such as COVID-19, malaria, and AIDS there is a clear urgency for more effective next-generation vaccines. One approach to improve the immunogenicity of vaccines is the use of nanoparticle platforms that present a repetitive array of antigen on its surface. This technology has been shown to improve antigen presenting cell uptake, lymph node trafficking, and B-cell activation through increased avidity and particle size. With a focus on design, we summarize natural platforms, methods of antigen attachment, and advancements in generating self-assembly that have led to new engineered platforms. We further examine critical parameters that will direct the usage and development of more effective platforms.