Potato, a component of global food security and economic stability, is cultivated extensively worldwide due to its adaptability to diverse climates and soil types. Ongoing research and technological advancements, including the use of unconventional products destined to fight the most harmful pathogens, are essential for enhancing productivity and resilience in potato farming. The current study aimed to identify the most appropriate fertilizers and phytosanitary treatments in order to attain optimal potato yields, dry matter, and starch contents, under climate-specific environments. The experiment was conducted in the northwest of Romania in 2023. The research was organized as a trifactorial experiment with the factors variety, fertilization, and phytosanitary treatment. XLSTAT (2022.2.1v.) was utilized for data processing. Mineral fertilization combined with conventional phytosanitary treatment led to the highest average yields in both potato varieties. Also, a combination of organic fertilization and treatment with 4% A. cepa extracts led to notable results, which suggests the possibility of successfully using these inputs in organic agriculture. The study shows the importance of selecting appropriate agricultural inputs to optimize potato yields, achieve specific levels of dry matter and starch content in a specific area, and promote sustainability.