The impact of freight on the transportation system is accentuated by the fact that trucks consume a greater roadway capacity than other vehicles and therefore cause more significant problems including traffic congestion, traffic delays, crashes, and pavement damage. Evaluating the actual repercussions of truck traffic becomes paramount in locales where roadway expansion is unfeasible. Trucks are vital to the economy, providing essential services to commerce and industry, and yet it is crucial that their operation does not contribute to the deterioration of infrastructural quality or compromise public safety. Currently, we lack methodologies in practice for the real-time management of traffic, specifically for truck routing, to minimize travel times and prevent delays due to non-recurrent congestion, such as traffic incidents. Accordingly, this study aimed to devise a truck routing strategy utilizing a traffic micro-simulation model (VISSIM) and to assess its effects on reducing travel delays. This involved the development of real-time truck re-routing simulation models that take into account non-recurrent congestion and the resulting travel delays and fuel consumption. The VISSIM model was applied to the I-75 corridor in Marion County, Florida, focusing on non-recurrent congestion effects on travel delays and fuel consumption. The initial findings suggest that the implementation of a dynamic truck re-routing system can significantly alleviate traffic congestion, resulting in a marked decrease in travel delays and fuel usage, demonstrating the potential for such strategies to enhance the overall efficiency of the transportation system.