Quality inspection plays a vital role in current manufacturing practice since the need for reliable and customized products is high on the agenda of most industries. Under this scope, solutions enhancing human–robot collaboration such as voice-based interaction are at the forefront of efforts by modern industries towards embracing the latest digitalization trends. Current inspection activities are often based on the manual expertise of operators, which has been proven to be time-consuming. This paper presents a voice-enabled ROS2 framework towards enhancing the collaboration of robots and operators under quality inspection activities. A robust ROS2-based architecture is adopted towards supporting the orchestration of the process execution flow. Furthermore, a speech recognition application and a quality inspection solution are deployed and integrated to the overall system, showcasing its effectiveness under a case study deriving from the automotive industry. The benefits of this voice-enabled ROS2 framework are discussed and proposed as an alternative way of inspecting parts under human–robot collaborative environments. To measure the added value of the framework, a multi-round testing process took place with different parameters for the framework’s modules, showcasing reduced cycle time for quality inspection processes, robust HRI using voice-based techniques and accurate inspection.