Mónica Lopez Redondo

Dr. Mónica Lopez Redondo

orcid

Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
13 March 2025 in Diagnostics
Verified
Journal Article
Open access
PDF file
MRMónica Lopez Redondo
Mónica Lopez Redondo
JVJuan Antonio Valera-Calero
Juan Antonio Valera-Calero
JAJavier Alvarez-González
Javier Alvarez-González
ARAlberto Roldán Ruiz
Alberto Roldán Ruiz
SSSandra Sanchez-Jorge
Sandra Sanchez-Jorge
DVDavinia Vicente
Davinia Vicente
Background/Objectives: The quadratus lumborum (QL) muscle is a key structure involved in patients with low back pain (LBP). Since the discriminative capability of morphological descriptors is uncertain and considering the high prevalence of myofascial trigger points and the poor reliability of manual palpation in this condition, developing a reliable procedure for assessing the QL’s tenderness is needed for facilitating the diagnosis and monitoring changes over time. We aimed to analyze the intra- and inter-examiner reliability of SWE for calculating the QL tenderness in patients with LBP. Methods: Using a convex transducer, longitudinal shear wave elastography (SWE) images of the QL muscle were acquired bilaterally twice in 52 volunteers with moderate LBP and disability by one experienced examiner and one novel examiner to measure shear wave speed and Young’s modulus as stiffness metrics. Results: Intra-examiner reliability estimates demonstrated high consistency independently of the examiner’s experience (intraclass correlation coefficients (ICCs) > 0.930) for both metrics. However, experienced examiners showed smaller minimal detectable changes. Additionally, inter-examiner reliability was lower, with ICCs ranging from 0.57 to 0.68, and significant differences in mean values between examiners (p < 0.01) were found. Conclusions: This procedure exhibited excellent intra-examiner reliability for assessing QL muscle stiffness in patients suffering LBP, indicating high repeatability of measurements when performed by the same examiner. In addition, experienced examiners demonstrated greater sensitivity in detecting real changes not attributed to measurement errors. However, inter-examiner reliability was moderate, highlighting the need for consistent examiner use to avoid measurement variability and averaging multiple measurements to enhance the accuracy.

5 February 2025 in Medicina
Verified
Journal Article
Open access
PDF file
MRMónica Lopez Redondo
Mónica Lopez Redondo
DVDavinia Vicente
Davinia Vicente
JAJavier Alvarez-González
Javier Alvarez-González
ARAlberto Roldán Ruiz
Alberto Roldán Ruiz
SSSandra Sanchez-Jorge
Sandra Sanchez-Jorge
JVJuan Antonio Valera-Calero
Juan Antonio Valera-Calero
Background and Objectives: Low back pain (LBP) is highly prevalent and often associated with altered muscle function, including in the quadratus lumborum (QL) muscle. While some studies have highlighted the clinical relevance of QL muscle stiffness in LBP, the findings remain inconsistent, and the role of this parameter in relation to clinical severity indicators is not well understood. Considering the high prevalence of myofascial trigger points among patients, objectively and reliably quantifying QL stiffness and its association with other clinical parameters could improve the identification of early stages of the condition before other alterations become apparent. Therefore, this study aimed to explore the association between QL stiffness and multiple indicators of LBP severity. Materials and Methods: A cross-sectional observational study was conducted involving the participation of seventy-six patients suffering from chronic LBP. An ultrasound scanner with shear-wave elastography (SWE) was used to determine the participants’ QL stiffness. Additional information was collected on LBP-associated pain intensity, disability, central sensitization, and quality of life. Results: QL muscle stiffness was negatively correlated with pain intensity (p < 0.01) and central sensitization (p < 0.01), and it was positively correlated with physical quality of life (p < 0.01). Muscle stiffness influenced the variance in pain intensity along with physical quality of life, central sensitization, and chronicity (together explaining 49% of the variance) but did not explain the variance in central sensitization. Conclusions: Assessing QL muscle stiffness in patients with LBP is recommended, as greater muscle softness is linked to higher pain intensity, central sensitization, and poorer physical quality of life. Regression analyses further highlighted that QL stiffness helps explain the variance in pain intensity, physical quality of life, central sensitization, and chronicity, but it did not directly affect the central sensitization variance.

29 December 2023 in Bioengineering
Verified
Journal Article
Open access
PDF file
JBJorge Buffet-García
Jorge Buffet-García
DVDavinia Vicente
Davinia Vicente
MRMónica Lopez Redondo
Mónica Lopez Redondo
SSSandra Sanchez-Jorge
Sandra Sanchez-Jorge
JAJavier Alvarez-González
Javier Alvarez-González
JVJuan Antonio Valera-Calero
Juan Antonio Valera-Calero
Limited evidence has verified if ultrasound imaging (US) can detect post-exercise muscle damage based on size, shape, and brightness metrics. This study aimed to analyze the correlation between creatine kinase (CK) concentration and (as a biomarker of muscle damage) changes in US gray-scale metrics after an exercise-induced muscle damage protocol. An observational study was conducted at a private university lab located in Madrid. Twenty-five untrained and asymptomatic volunteers were enrolled in this study. Baseline demographic data and body composition metrics were collected. In addition, the rectus femoris US data and CK concentration were assessed at baseline and after inducing muscle damage (24 and 48 h later). After calculating time differences for all the outcomes, the correlation between the changes observed with US and biomarkers was assessed. Significant CK concentration increases were found 24 h (p = 0.003) and 48 h (p < 0.001) after exercise. However, no significant changes in muscle size, shape, or brightness were found in any location (p > 0.05 for all). In addition, no significant associations were found between CK changes and US changes (p > 0.05 for all). Gray-scale US is not a sensitive tool for detecting muscle damage, as a protocol of exercise-induced muscle damage confirmed with CK produced no significant gray-scale US changes after 24 or 48 h. In addition, US and CK changes after 24 and 48 h were not associated with each other.

16 May 2024 in Bioengineering
Verified
Journal Article
Open access
PDF file
UVUmut Varol
Umut Varol
JVJuan Antonio Valera-Calero
Juan Antonio Valera-Calero
RORicardo Ortega‐Santiago
Ricardo Ortega‐Santiago
MRMónica Lopez Redondo
Mónica Lopez Redondo
MNMarcos Jose Navarro-Santana
Marcos Jose Navarro-Santana
PPPedro Belon Perez
Pedro Belon Perez
This study aimed to evaluate the inter-examiner reliability of shear wave elastography (SWE) for measuring cervical multifidus (CM) muscle stiffness in asymptomatic controls and patients with chronic neck pain. A longitudinal observational study was conducted to assess the diagnostic accuracy of a procedure. SWE images, following a detailed procedure previously tested, were acquired by two examiners (one novice and one experienced) to calculate the shear wave speed (SWS) and Young’s modulus. The painful side was examined for the experimental cases while the side examined in the control group was selected randomly. Data analyses calculated the intra-class correlation coefficients (ICCs), absolute errors between examiners, standard errors of measurement, and minimal detectable changes. A total of 125 participants were analyzed (n = 54 controls and n = 71 cases). The Young’s modulus and SWS measurements obtained by both examiners were comparable within the asymptomatic group (both, p > 0.05) and the chronic neck pain group (both, p > 0.05). Nonetheless, a notable distinction was observed in the absolute error between examiners for shear wave speed measurements among patients with neck pain, where a significant difference was registered (p = 0.045), pointing to a sensitivity in measurement consistency affected by the presence of chronic neck pain. ICCs demonstrated moderate-to-good reliability across both groups, with ICC values for asymptomatic individuals reported as >0.8. Among the chronic neck pain patients, ICC values were slightly lower (>0.780). The study revealed moderate-to-good consistency, highlighting the practicality and generalizability of SWE.

8 July 2025 in European Spine Journal
Verified
Journal Article
Open access
PDF file
MRMónica Lopez Redondo
Mónica Lopez Redondo
DVDavinia Vicente
Davinia Vicente
JAJavier Alvarez-González
Javier Alvarez-González
ARAlberto Roldán Ruiz
Alberto Roldán Ruiz
SSSandra Sanchez-Jorge
Sandra Sanchez-Jorge
JVJuan Antonio Valera-Calero
Juan Antonio Valera-Calero
Background: Evaluation of muscle tenderness is encouraged in the diagnosis of low back pain (LBP). However, manual palpation is poorly reliable and objective methods to quantify muscle stiffness are needed. Objectives: To investigate quadratus lumborum muscle stiffness differences between individuals with chronic non-specific low back pain (LBP) and pain-free controls, analyze side-to-side stiffness differences, and assess the diagnostic accuracy of shear wave elastography. Methods: A cross-sectional study was conducted recruiting 40 patients with chronic non-specific LBP and 40 asymptomatic controls. Variables assessed included muscle stiffness using shear wave elastography metrics (shear wave speed (SWS) and Young’s modulus (YM)), pain chronicity, pain intensity, pain-related disability (using the Oswestry Disability Index) and symptoms associated with central sensitization (using the Central Sensitization Inventory). Diagnostic accuracy was evaluated through sensitivity, specificity, and receiver operating characteristic analysis. Results: No significant side-to-side stiffness differences were observed within either group (both, p > 0.05). Quadratus lumborum muscle stiffness was significantly lower in LBP patients compared to controls (SWS p = 0.010; YM p = 0.008). The receiver operating characteristic analysis for both metrics showed poor discriminatory ability (< 0.7). A modest balance between sensitivity (SWS 70%; YM 75%) and specificity (SWS 97.5%; YM 50%) was found. Conclusions: Although greater stiffness was expected due to the associated prevalence of trigger points in patients with LBP, quadratus lumborum muscle stiffness was significantly lower in patients suffering chronic non-specific LBP compared to controls. Despite significant differences, the diagnostic accuracy of shear wave elastography was poor, requiring further research to improve the diagnostic utility of shear wave elastography.

7 November 2024 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
JVJuan Antonio Valera-Calero
Juan Antonio Valera-Calero
UVUmut Varol
Umut Varol
GPGustavo Plaza-Manzano
Gustavo Plaza-Manzano
César Fernandez-de-las-PeñasCésar Fernandez-de-las-Peñas
César Fernandez-de-las-Peñas
PPPedro Belon Perez
Pedro Belon Perez
MNMarcos Jose Navarro-Santana
Marcos Jose Navarro-Santana
Objectives: The dry needling of the piriformis muscle (especially in the medial region) is a challenging procedure since there is a high risk of accidentally puncturing the sciatic nerve. This study aimed to explain the variance of the deep limit of the piriformis based on anthropometric and demographic predictors potentially associated with it by exploring if clinicians can select the optimal needle length needed accurately to avoid accidental punctures of the sciatic nerve during palpation-guided dry needling interventions. Methods: An observational study was conducted that included fifty-six patients with piriformis muscle syndrome. We recorded the skin-to-sciatic nerve distance at the location with greatest risk of accidental sciatic puncture (assessed with ultrasound imaging) and demographic (e.g., age, gender, height, weight and body mass index—BMI) and anthropometric (hip circumference) variables. Results: Thirty-four males (n = 34) and twenty-two females (n = 22) were analyzed. Although men presented a significantly greater hip circumference than women (p = 0.007), no skin-to-sciatic nerve distance differences were observed (p > 0.05). Correlation analyses revealed that the sciatic nerve’s depth is associated with weight, BMI and hip perimeter (all, p < 0.01) but not with age or height (p > 0.05). Due to shared variance and multicollinearity, the hip circumference was the only predictor included in the regression model, explaining 37.9% of the piriformis muscle’s deeper fascia depth variance (R2 Adjusted = 0.379). Conclusions: Although the use of landmarks and measuring the hip perimeter may result in greater dry needling accuracy and a lower risk of adverse events derived from accidental sciatic nerve puncture, ultrasound guidance is encouraged as is the safest method for avoiding serious adverse events.