Growing high-quality crystals with ideal properties is of great importance. The morphology of crystal is one key factor reflecting product quality, as it can affect the performance of products and downstream operations. In this work, the current state of crystal morphology modification is reviewed from different perspectives. First, the most widely used crystal growth models are discussed. Then, a variety of crystal morphology control methods, which include adjustment of crystallization operation parameters, addition of foreign molecules, change of different solvents, membrane assistance, the addition of external physical fields and the use of ball milling are summarized. As for applications, the control of crystal morphology has application potential in pharmaceutical and material fields, for example, energetic materials and semiconductor materials. Finally, the future development direction of crystal morphology regulation is discussed.

Pd-catalyzed ortho -C(sp ³ )–H arylation of aromatic aldehydes using 2-amino- N -methyl-acetamide as a simple, efficient and commercially available L,L-type transient directing group (TDG) is reported.

These solid–liquid phase equilibrium models can facilitate precise phase equilibrium calculations, guide the appropriate model selection, and enhance their predictive capabilities through integration with machine learning.

Owing to their excellent biocompatibility and antibacterial properties, the global annual production of silver nanoparticles (AgNPs) is estimated at 400-800 tons. Therefore, developing a green and safe approach for AgNPs synthesis is urgently required. However, the conventional AgNPs manufacturing methods required toxic reductant and higher energy consumption, which makes the reaction system harmful to humans and environment. In this study, an eco-friendly ultrasound-intensified continuous system employing minimal toxic reagents was developed. The AgNPs formation process was intensified by cavitation instead of using toxic and strong reductants. Several analytical methods were conducted to systematically investigate the mechanism and performance of as-synthesized AgNPs, such as particle size distribution, zeta potential, UV-visible absorption, morphology, yield calculation, as well as in vitro photothermal, and antibacterial. The results clearly indicated that the physicochemical properties of AgNPs could be tuned by adjusting process parameters, including temperature, feeding rate, and ultrasonic power. Specifically, the AgNPs prepared at 90 ℃, 600 W and 50 µL/min exhibited smaller size (2-5 nm) with monodisperse, spherical shape, higher yield, enhanced photothermal, and antibacterial activities. Furthermore, life-cycle assessment (LCA) and machine learning (ML) were employed to evaluate the process sustainability and identify the key influencing parameters. Comprehensive consideration of safety, experimental results, and LCA outcomes demonstrated that the ultrasound-intensified continuous method proposed in this study is superior to the traditional NaBH₄-based batch synthesis at the laboratory scale.

A novel synthetic strategy for indanones was established through a Pd-catalyzed direct annulation of benzaldehydes with norbornenes assisted by anilines as monodentate transient directing groups. The reaction proceeds smoothly under mild conditions and generates indanones with moderate to excellent yields. This protocol exhibits a broad functional group compatibility and high atom economy. Mechanistic investigations revealed that consecutive ortho aromatic C–H and carbonyl C–H activations of benzaldehydes are involved in the reaction.