Since increasing evidence underlines the prominent role of systemic inflammation in carcinogenesis, the inflammation burden index (IBI) has emerged as a promising biomarker to estimate survival outcomes among cancer patients. The IBI has only been validated in Eastern gastric cancer (GC) patients; therefore, the aim of this study was to evaluate the IBI as a prognostic biomarker in Central European GC patients undergoing multimodal treatment. Ninety-three patients with histologically confirmed GC who underwent multimodal treatment between 2013 and 2021 were included. Patient recruitment started with the standardization of neoadjuvant chemotherapy (NAC). Blood samples were obtained one day prior to surgical treatment. The textbook outcome (TO) served as the measure of surgical quality, and tumor responses to NAC were evaluated according to Becker’s system tumor regression grade (TRG). A high IBI was associated with an increased risk of postoperative complications (OR 2.95, 95% CI 1.13–7.72). In multivariate analysis, a high IBI (HR = 2.56, 95% CI 1.28–5.13) and a high neutrophil-to-lymphocyte ratio (NLR, HR = 2.55, 95% CI 1.32–4.94) were associated with an increased risk of death, while NAC administration (HR = 0.40, 95% CI 0.18–0.90) and TO achievement (HR = 0.42, 95% CI 0.22–0.81) were associated with a lower risk of death. The IBI was associated with postoperative complications and mortality among GC patients undergoing multimodal treatment.

Purpose The rising proportion of patients diagnosed with early-stage breast cancer (BC) has shifted the focus of oncological care toward patient-reported outcomes (PROs) as an important component of treatment evaluation. Nevertheless, data on the association between body composition and BC-specific PROs remain scarce and mainly retrospective. This study aimed to evaluate the association between preoperative bioelectrical impedance analysis (BIA) parameters and BC-specific PROs measured using the EORTC QLQ-BR23. Methods This prospective study included 81 patients with histologically confirmed BC qualified for surgical treatment. Body composition was assessed preoperatively using multi-frequency BIA. BC-specific PROs was evaluated using the EORTC QLQ-BR23 questionnaires. Statistical analysis included the Mann-Whitney U test and Kruskal-Wallis ANOVA for group comparisons and Spearman’s rank correlation coefficient to assess associations between variables. Results Significant associations were observed between selected BIA parameters and PROs in BC patients. Higher phase angle and reactance values were positively correlated with body image, whereas higher lower-limb fat-free mass percentage and elevated TBW/FFM ratios were associated with poorer sexual functioning and enjoyment. In addition, body composition parameters differed across molecular subtypes with HER2-positive patients demonstrating lower values of total body water, fat-free mass, skeletal muscle mass and basal metabolic rate. Conclusion These findings support the clinical utility of BIA as a complementary tool for personalized assessment linking physiological status with tumor characteristics and PROs.

Introduction: Botulinum toxin is one of the most powerful neurotoxins currently known, with high affinity to the cholinergic synapse, which sufficiently inhibits the release of acetylcholine. Its use has proved to be effective in the treatment of many diseases of the musculoskeletal system. Although most of the therapeutic effects of botulinum toxin are due to the temporary relaxation of skeletal muscles (caused by inhibition of acetylcholine release), research is ongoing into its effects on the nervous system. Purpose of the work: The aim of the study is to analyze the effectiveness of botulinum toxin in the treatment of neuralgia and neuropathic pain. Method: The relevant samples were accessed by means of an electronic search in the PubMed database. The analysis used reviews and meta-analyzes posted on the platform over the last 10 years. Conclusions: Botulinum toxin has great potential in the treatment of pain. It is multitasking due to its favorable safety profile and long-lasting relief from a single injection compared to other pain medications. The side effects caused by it were assessed to be mild to moderate and included a local skin reaction (swelling), injection site pain, muscle weakness, flu symptoms, nausea and vomiting. Keywords: botulinum toxin; neuropathic pain; pain treatment; neuralgia; BoNT / A

Introduction: Insulin resistance is the first stage of diabetes development. It has been defined as a dysmetabolic state in which the biological response of target tissues (particularly liver, muscle and adipose tissue) to circulating insulin is impaired. This leads to hyperinsulinemia, which in turn leads to obesity and type 2 diabetes (T2D). The basic ingredients of the Mediterranean diet, such as fruit, vegetables, fish rich in fat, extra virgin olive oil, tree nuts, red wine, have been defined in the functional food model by the natural content of nutraceuticals such as polyphenols, terpenoids, flavonoids, alkaloids, sterols and unsaturated fatty acids. Purpose of the work : Demonstrate the beneficial effects of implementing the Mediterranean diet in patients with insulin resistance or type 2 diabetes. The appropriate samples were accessed using a search engine in the PubMed database. The reviews and meta-analyzes published over the last 10 years were used. Results: After changing the diet to a diet rich in these nutrients, a greater improvement in IR was shown in obese people compared to other diets. In addition, dietary polyphenols demonstrated clinically significant benefits in metabolic and microvascular functions leading to lowering of fasting cholesterol and glucose, and anti-inflammatory and antioxidant properties in high-risk and T2DM patients. Conclusions: Mediterranean diets with the addition of extra virgin olive oil or nuts reduced total body weight and improved glucose metabolism.

Introduction: rosacea affects approximately 10% of the world's population. It is a recurrent, inflammatory dermatosis that is difficult to deal with despite treatment. Material and methods: literature review from PubMed databases from 2017-2022. Conclusions: It is very difficult to find the cause of acne lesions. What is certain is that various factors overlap: genetic, environmental, immunological disorders, intestinal abnormalities, dietary factors. New treatments are constantly being sought. The overall health of the organism is very important in maintaining the proper function of every organ, but also of the skin - as a barrier against rosacea.