Background: Metabolic endotoxemia, characterized by chronic low-grade elevation of circulating bacterial endotoxins such as lipopolysaccharides derived from Gram-negative bacteria, has emerged as a central focus in metabolic disease research. Notably, emerging evidence highlights the pivotal role of gut microbiota in driving this condition, though critical knowledge gaps persist regarding the precise mechanisms mediated by gut microbiota-derived metabolites and their specific signaling pathways, as well as the development of individualized intervention strategies. To systematically map the evolving research landscape, this review employs bibliometric analysis to identify emerging trends and patterns in understanding the interplay between metabolic endotoxemia and gut microbial communities.Materials and methods: This study employed a comprehensive bibliometric analysis of scholarly literature indexed in the Web of Science Core Collection (1900–2024) to investigate research patterns in metabolic endotoxemia and gut microbiota. Through multidimensional examination using VOSviewer, CiteSpace, the bibliometrix R package, and the online bibliometric analysis platform (https://bibliometric.com/), we systematically mapped research priorities, collaborative networks, and evolving frontiers in this interdisciplinary field. The methodology incorporated advanced visualization techniques and quantitative assessments to identify thematic clusters, institutional contributions, and knowledge diffusion pathways within the extant literature corpus.Results: This comprehensive global analysis, encompassing 1,585 relevant studies, demonstrates compelling evidence that China and USA collectively contribute over 50% of scientific output in this specialized research domain. Notably, academic investigations into metabolic endotoxemia and gut microbiota continue to maintain substantial research momentum. Current scholarly discourse prominently features five key thematic clusters: gut dysbiosis, intestinal barrier, risk, gut-liver axis, and short-chain fatty acids.Conclusion: This in-depth review systematically examines the evolving research landscape and emerging investigative priorities in metabolic endotoxemia and gut microbiota. It equips researchers with a comprehensive overview of key contributors in these specialized fields, including leading nations, institutions, academic journals, and potential collaborative networks. The analysis further delineates cutting-edge research frontiers and proposes strategic directions for future investigation, thereby serving as an invaluable resource for scholars navigating the complex interplay between metabolic endotoxemia and gut microbiota in the intestinal ecosystem.

Synthetic lethality describes situations in which defects in two different genes or pathways together result in cell death. This concept has been applied to drug development for cancer treatment, as represented by Poly (ADP-ribose) polymerase (PARPs) inhibitors. In the current study, we performed a computational screening to discover new PARP inhibitors. Among the 11,247 compounds analyzed, one natural product, ZINC67913374, stood out by its superior performance in the simulation analyses. Compared with the FDA approved PARP1 inhibitor, olaparib, our results demonstrated that the ZINC67913374 compound achieved a better grid score (−86.8) and amber score (−51.42). Molecular dynamics simulations suggested that the PARP1-ZINC67913374 complex was more stable than olaparib. The binding free energy for ZINC67913374 was −177.28 kJ/mol while that of olaparib was −159.16 kJ/mol. These results indicated ZINC67913374 bound to PARP1 with a higher affinity, which suggest ZINC67913374 has promising potential for cancer drug development.

Background: In recent years, the prevalence of childhood obesity has escalated alarmingly, posing significant threats to the physical and mental well-being of children, with an elevated likelihood of persisting into adulthood. Notably, recent investigations have uncovered a profound association between intestinal microbiota, a crucial component of the internal milieu, and childhood obesity. Disturbances in intestinal microbiota and their by-products are now understood to be profoundly intertwined with the evolutionary pathway of childhood obesity. Bibliometric analysis offers a deep understanding of the current research landscape, so we apply it to a review of the emerging trends and patterns between childhood obesity and gut microbiota.Materials and methods: We conducted a rigorous and extensive search of the Web of Science (WoS) Core Collection database, spanning the years from 1900 to 2023, to analyze scholarly articles pertaining to childhood obesity and gut microbiota. Utilizing VOSviewer, CiteSpace, the R package “bibliometrix,” and the online bibliometric analysis platform (https://bibliometric.com/), we delved into the intricate details of research hotspots, academic collaborations, and emerging trends within this domain.Results: The exhaustive search encompassed the globe, uncovering a cumulative total of 1,384 pertinent studies originating from 429 nations. The results were compelling, revealing a profound influence exerted by the United States and China in this specific field of research. Furthermore, it was observed that the volume of scholarly works pertaining to childhood obesity and gut microbiota is steadily growing year on year. The current hot topics in this field include “abuse,” “maltreatment,” “adverse childhood experiences,” “students,” and “food addiction”.Conclusion: This comprehensive review offers a meticulous exploration of the evolving trends and emerging research agendas pertaining to childhood obesity and gut microbiota over the past two decades. It strives to equip researchers with a thorough understanding of the key nations, institutions, journals, and potential collaborators in these specialized fields. Additionally, it sheds light on the current frontiers of research and strategic avenues for further exploration, thus serving as an invaluable resource for scholars delving deeper into the intricacies of childhood obesity and the gut microbiome.