Christophe Moser

Dr. Christophe Moser


Research Focus & Metrics

Academic Career Length

27Years (2000-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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19 August 2019 in Advanced Materials
Verified
Journal Article
Open access
PDF file
PBPaulina Núñez Bernal
Paulina Núñez Bernal
PDPaul Delrot
Paul Delrot
DLDamien Loterie
Damien Loterie
YLYang Li
Yang Li
JMJos Malda
Jos Malda
RLRiccardo Levato
Riccardo Levato
Biofabrication technologies, including stereolithography and extrusion‐based printing, are revolutionizing the creation of complex engineered tissues. The current paradigm in bioprinting relies on the additive layer‐by‐layer deposition and assembly of repetitive building blocks, typically cell‐laden hydrogel fibers or voxels, single cells, or cellular aggregates. The scalability of these additive manufacturing technologies is limited by their printing velocity, as lengthy biofabrication processes impair cell functionality. Overcoming such limitations, the volumetric bioprinting of clinically relevant sized, anatomically shaped constructs, in a time frame ranging from seconds to tens of seconds is described. An optical‐tomography‐inspired printing approach, based on visible light projection, is developed to generate cell‐laden tissue constructs with high viability (>85%) from gelatin‐based photoresponsive hydrogels. Free‐form architectures, difficult to reproduce with conventional printing, are obtained, including anatomically correct trabecular bone models with embedded angiogenic sprouts and meniscal grafts. The latter undergoes maturation in vitro as the bioprinted chondroprogenitor cells synthesize neo‐fibrocartilage matrix. Moreover, free‐floating structures are generated, as demonstrated by printing functional hydrogel‐based ball‐and‐cage fluidic valves. Volumetric bioprinting permits the creation of geometrically complex, centimeter‐scale constructs at an unprecedented printing velocity, opening new avenues for upscaling the production of hydrogel‐based constructs and for their application in tissue engineering, regenerative medicine, and soft robotics.

12 February 2020 in Nature Communications
Verified
Journal Article
Open access
PDF file
DLDamien Loterie
Damien Loterie
PDPaul Delrot
Paul Delrot
CMChristophe Moser
Christophe Moser
In tomographic volumetric additive manufacturing, an entire three-dimensional object is simultaneously solidified by irradiating a liquid photopolymer volume from multiple angles with dynamic light patterns. Though tomographic additive manufacturing has the potential to produce complex parts with a higher throughput and a wider range of printable materials than layer-by-layer additive manufacturing, its resolution currently remains limited to 300 µm. Here, we show that a low-étendue illumination system enables the production of high-resolution features. We further demonstrate an integrated feedback system to accurately control the photopolymerization kinetics over the entire build volume and improve the geometric fidelity of the object solidification. Hard and soft centimeter-scale parts are produced in less than 30 seconds with 80 µm positive and 500 µm negative features, thus demonstrating that tomographic additive manufacturing is potentially suitable for the ultrafast fabrication of advanced and functional constructs.

20 August 2021 in Nature Computational Science
Verified
Journal Article
Closed access
PDF file
UTUğur Teğin
Uğur Teğin
MYMustafa Yıldırım
Mustafa Yıldırım
IOİlKer Oğuz
İlKer Oğuz
CMChristophe Moser
Christophe Moser
DPDemetri Psaltis
Demetri Psaltis

4 November 2019 in Optica
Verified
Journal Article
Closed access
PDF file
UTUğur Teğin
Uğur Teğin
EKEirini Kakkava
Eirini Kakkava
BRBabak Rahmani
Babak Rahmani
DPDemetri Psaltis
Demetri Psaltis
CMChristophe Moser
Christophe Moser
Spatiotemporal mode-locked fiber lasers are a type of ultrafast lasers for which the longitudinal and transverse modes of the multimode fiber cavities are locked via nonlinear interaction in the cavity. Here we report the experimental realization of a spatiotemporally mode-locked fiber laser with self-similar pulse evolution. The multimode fiber oscillator generates parabolic pulses at 1030 nm with 90 mW average power, a near-Gaussian beam quality (M2≤1.4), and 2.3 ps (192 fs externally dechirped) pulse duration. Numerical simulations confirm the experimental observations of self-similar pulse propagation. These results will enable further investigation of nonlinear dynamics in spatiotemporal mode-locked fiber lasers.

31 July 2024 in Nature Photonics
Verified
Journal Article
Open access
PDF file
MYMustafa Yildirim
Mustafa Yildirim
NDNiyazi Ulas Dinc
Niyazi Ulas Dinc
IOIlker Oguz
Ilker Oguz
DPDemetri Psaltis
Demetri Psaltis
CMChristophe Moser
Christophe Moser
Deep neural networks have achieved remarkable breakthroughs by leveraging multiple layers of data processing to extract hidden representations, albeit at the cost of large electronic computing power. To enhance energy efficiency and speed, the optical implementation of neural networks aims to harness the advantages of optical bandwidth and the energy efficiency of optical interconnections. In the absence of low-power optical nonlinearities, the challenge in the implementation of multilayer optical networks lies in realizing multiple optical layers without resorting to electronic components. Here we present a novel framework that uses multiple scattering, and which is capable of synthesizing programmable linear and nonlinear transformations concurrently at low optical power by leveraging the nonlinear relationship between the scattering potential, represented by data, and the scattered field. Theoretical and experimental investigations show that repeating the data by multiple scattering enables nonlinear optical computing with low-power continuous-wave light. Moreover, we empirically find that scaling of this optical framework follows a power law.

18 May 2022 in Advanced Science
Verified
Journal Article
Open access
JMJorge Madrid-Wolff
Jorge Madrid-Wolff
ABAntoine Boniface
Antoine Boniface
DLDamien Loterie
Damien Loterie
PDPaul Delrot
Paul Delrot
CMChristophe Moser
Christophe Moser
3D printing has revolutionized the manufacturing of volumetric components and structures in many areas. Several fully volumetric light‐based techniques have been recently developed thanks to the advent of photocurable resins, promising to reach unprecedented short print time (down to a few tens of seconds) while keeping a good resolution (around 100 μm). However, these new approaches only work with homogeneous and relatively transparent resins so that the light patterns used for photo‐polymerization are not scrambled along their propagation. Herein, a method that takes into account light scattering in the resin prior to computing projection patterns is proposed. Using a tomographic volumetric printer, it is experimentally demonstrated that implementation of this correction is critical when printing objects whose size exceeds the scattering mean free path. To show the broad applicability of the technique, functional objects of high print fidelity are fabricated in hard organic scattering acrylates and soft cell‐laden hydrogels (at 4 million cells mL−1). This opens up promising perspectives in printing inside turbid materials with particular interesting applications for bioprinting cell‐laden constructs.