Grapevine is a highly climate-sensitive plant. In the last few decades, an increase in the number and area of vineyards has been observed in the country, with the Zielona Góra region pioneering this revival. A comprehensive analysis of climatic and agroclimatic indicators for grapevines was conducted to assess the possibilities and limitations in this region. Based on data obtained from the Institute of Meteorology and Water Management—National Research Institute (IMGW-PIB) for stations in Zielona Góra, nine key indicators were identified. The analysis of agroclimatic conditions for the Zielona Góra winegrowing region from 1951 to 2022 revealed significant changes in air temperature, length of the vegetative period, and number of frosts. The average annual air temperature increased, while the number of days with temperatures below 8 °C decreased. The extension of the vegetative period (starting earlier and ending later) favours grapevine cultivation. The increase in temperature during the vegetative period and the lengthening of the frost-free period have a beneficial effect on grape production in the Zielona Góra region.