Prof. Dr. Dae Hoon Kim

Spontaneous oscillation of tone of blood vessel called vasomotion cause vessel to flow blood which is an oscillation of flow into an organ. Microcirculation is sensitive to hypoxic condition and metabolism but mechanism of vasomotion is still poorly understood. Purpose: We studied involvement of metabolism-mediated regulation by intracellular ATP level of vasomotion in human gastric artery. Methods: Conventional contractile measuring system and Western blot were used. Circular muscle of human gastric artery produced sustained tonic contraction of 1.0 ± 0.19 g by 50 mM high K+ (n = 36). Pinacidil (10 μM), which is known to activatorof ATP-sensitive K+ (KATP) channel inhibited vasomotion completely in a reversible manner. Inhibition of vasomotion by activators of KATP channel recovered by glibenclamide. Diazoxide (300 μM), cromakalim (10 μM) nicorandil (10 μM) which is known to activate KATP channel also completely blocked vasomotion in a glibenclamide sensitive manner. Inhibitory effect of these openers of KATP channel on serotonin and norepinephrine-induced contraction were also recoded in a glibenclmide-sensitive manner. In human artery, glucose-free condition which is elated metabolic changes inhibited vasomotion and it was recovered by glibenclamide. Finally, molecular subtypes of KATP channel was defined by Western blot in human artery. Vasomotion of human gastroepiploic artery was inhibited by activation of specific subtypes of KATP channel and alteration of metabolism.

About Me

Dae Hoon Kim, MD, PhD Professor of Surgery, Chungbuk National University College of Medicine, Korea. Dr. Kim’s research spans gastrointestinal surgical oncology, bariatric-metabolic surgery, and the integration of AI-based surgical techniques. He has served as first or corresponding author on over 20 peer-reviewed articles, including: Changes in Postoperative Recurrence and Prognostic Risk Factors for Patients with Gastric Cancer Who Underwent Curative Gastric Resection during Different Time Periods (Annals of Surgical Oncology) Vasomotion in Human Arteries and Their Regulations Based on Ion Channel Regulations: 10-Year Study (Journal of Cell Physiology) The Relationships Between Perioperative CEA, CA 19-9, and CA 72-4 and Recurrence in Gastric Cancer Patients After Curative Radical Gastrectomy (Journal of Surgical Oncology) Preoperative CA 125 Is a Significant Indicator of Curative Resection in Gastric Cancer Patients (World Journal of Gastroenterology) His current projects focus on developing deep-learning models for intraoperative guidance and radiomics-driven risk stratification in gastric cancer and metabolic surgery.

Prof. Dr. Dae Hoon Kim

Prof. Dr. Dae Hoon Kim

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