Inflammatory dermatological diseases represent a significant global health burden, with emerging evidence suggesting that modulation of the gut–skin axis microbial interventions may offer therapeutic benefits. However, current evidence is fragmented, with considerable heterogeneity limiting definitive conclusions. A systematic review and a meta-analysis were conducted following PRISMA guidelines, registered in PROSPERO (CRD42024629809). Seven databases were searched for randomized controlled trials evaluating probiotics, synbiotics, or postbiotics in inflammatory skin conditions. Primary outcomes included disease severity scores (SCORAD for atopic dermatitis, PASI for psoriasis). Statistical analysis employed random-effect models with standardized mean differences (SMDs) and Hedges’ g as effect size measures, using R software. Heterogeneity among studies was assessed using Q statistics and the I² index. Results: In total, 19 studies encompassing 1104 participants met the inclusion criteria. For atopic dermatitis, a meta-analysis of 12 studies (n = 817) demonstrated significant clinical improvement with microbial interventions versus placebo (SMD = −0.72; 95% CI: −1.26 to −0.17; p = 0.015), though substantial heterogeneity in the treatment effects was observed across studies (I² = 85.1%). The psoriasis results were more variable, with five studies (n = 287) showing non-significant pooled effects (SMD = −0.63; 95% CI: −1.74 to 0.48; p = 0.192). Multi-strain formulations and synbiotic combinations appeared to show greater efficacy compared to single-strain preparations. Safety profiles remained consistently favorable across all interventions. Microbial interventions represent a promising adjunctive therapeutic approach for inflammatory dermatological diseases, particularly atopic dermatitis, acting via gut–skin axis mechanisms. The substantial heterogeneity between the included studies emphasizes the need for standardized protocols and personalized medicine approaches integrating microbiome profiling to optimize clinical outcomes.

Cutaneous leishmaniasis (CL) is a zoonotic disease caused by protozoa of the Leishmania genus, transmitted by vectors from the Phlebotominae subfamily. The interaction between the vector, reservoir, and parasite is susceptible to climate change. This study explores how temperature and rainfall influenced the incidence of CL in 15 Colombian municipalities between 2017 and 2019. Epidemiological data were obtained from Colombia’s Instituto Nacional de Salud, while climatological data came from the Instituto de Hidrología, Meteorología y Estudios Ambientales. Using Spearman’s rank correlation coefficient, we examined the relationships between monthly climatic variables and the cumulative incidence of CL, considering various lag times. The data were further analyzed using Locally Weighted Scatterplot Smoothing (LOWESS). Our findings reveal both significant positive and negative correlations, depending on locality and climate variables. LOWESS analysis indicates that while rainfall-related incidence remains stable, temperature impacts incidence in a parabolic trend. This study underscores the significant yet complex influence of climatic factors on CL incidence. The insights gained could aid public health efforts by improving predictive models and crafting targeted interventions to mitigate the disease’s impact, particularly in regions vulnerable to climate variability.

La porencefalia como lesión cerebral es una entidad que por el gran compromiso encefálico genera déficits motores y conductuales afectando el normal desarrollo de niños, siendo este el grupo poblacional principalmente afectado; quienes desde muy temprana edad presentan manifestaciones clínicas, sin embargo en algunos casos excepcionales tienden a cursan asintomáticos o con mínimas secuelas motoras que pueden retrasar su diagnóstico; campo en que las técnicas de imagen llegan a ser fundamentales. Se presenta aquí el primer caso de porencefalia reportado en Boyacá a la edad adulta sin antecedentes que sugieran su diagnóstico o algún manejo instaurado a la misma, la cual termina complicándose dejando varias secuelas.