For the excellent drug delivery systems, advanced functional materials are indispensable. In recent years, mesoporous materials have shown a promising prospect and attracted much attention in the field of drug delivery. The research of mesoporous materials as drug carriers becomes to be a hot-spots. As a drug vehicle, it is favored by scientists due to the advantages in increasing drug dissolution and bioavailability, improving drug stability, sustained and controlled drug release, reducing drug side effects, good biocompatibility, targeting and so on. The anticipated in vivo performance for the mesoporous materials based drug delivery systems can be improved through optimizing the synthesis conditions or modifying the materials. In the paper, mesoporous silica nanoparticles (MSNs), mesoporous carbon nanoparticles (MCNs), organic frameworks (OFs), mesoporous hydroxyapatite (mHAp) are selected as the representative mesoporous materials. The structural characteristics, preparation methods, application in the field of drug delivery of above materials are reviewed, and the future research is prospected.

In this study, a clear correlation between the in vitro and in vivo cellular uptake and trafficking was discovered by delivering miktoarm copolymer nanomicelles (MCNs) to cancer cells and tumor tissues. To monitor this process, two different FRET pairs, DiO and DiI, DiD and DiR, were loaded into MCNs to monitor the Förster resonance energy transfer (FRET) efficiency. The change in FRET efficiency in vitro and in vivo demonstrated a similar sequence of events for the transport of MCNs: hyperbranched block PCL inserted into cytomembrane, while the loaded hydrophobic fluorescence probes were released and followed by time-dependent intracellular clustering within endocytic vesicles. Additionally, uptake of loaded fluorescence probes with successively increasing ratios of copolymers suggested that with the increase of mass ratio of copolymer to fluorescence probes, cellular uptake of probes significantly decreased. This result was also consistent with the uptake behavior in cancer tissues. Collectively, the interaction between MCNs and cellular membrane dictated the uptake and trafficking of core-loaded hydrophobic probes. This concept paves a new way to analyze in vitro-in vivo correlation of other nanocarriers for endocytosis mechanism studies as well as further novel copolymers design in biomedical applications.

In this work, PdPt bimetallic nanoparticles with robust oxidase-like activity were synthesized, based on which a label-free, H₂O₂-free colorimetric platform was constructed for gossypol detection. The PdPt nanozyme activates dissolved...