With the rapid advancement of information and communication technology (ICT), big data, and artificial intelligence (AI), intelligent healthcare systems have emerged, including the integration of healthcare systems with capital, the introduction of healthcare systems into long-term care institutions, and the integration of measurement data for care or exposure. These systems provide comprehensive communication and home exposure reports and enable the involvement of rehabilitation specialists and other experts. Silver technology enables the realization of health management in long-term care services, workplace care, and health applications, facilitating disease prevention and control, improving disease management, reducing home isolation, alleviating family burden in terms of nursing, and promoting health and disease control. Research and development efforts in forward-looking cross-domain precision health technology, system construction, testing, and integration are carried out. This integrated project consists of two main components. The Integrated Intelligent Long-Term Care Service Management System focuses on building a personalized care service system for the elderly, encompassing health, nutrition, diet, and health education aspects. The Wearable Internet of Things Care System primarily supports the development of portable physiological signal detection devices and electronic fences.

This study aimed to investigate level of work ability and quality of life (QOL) as well as the relationship between them among patients suffering from work-related musculoskeletal disorders (WMSDs) in Taiwan. A cross-sectional study design with continuous sampling and a questionnaire were used to obtain the research data. Controlling for personal characteristics, pain, psychological distress, and social support, multiple linear regressions were adopted to explore the relationship between work ability and overall QOL. Further analyses were also made to clarify the relationships between work ability and each domain of QOL. In total, 165 patients with WMSDs were recruited. Compared with general workers, the participants reported a lower level of work ability and overall QOL. Work ability was significantly associated with overall QOL when covariates were controlled. Among the four domains of QOL, work ability was significantly associated with both the physical and psychological domains. The conclusion was that work ability is a definite factor of QOL for patients with WMSDs; the essence of work ability may be beyond economic function or social support. Strategies to help workers with WMSDs enhance their work ability to fit their new or temporary jobs would be beneficial to their QOL.

Sericin, a textile waste, can be used for antioxidant and skin-whitening purposes. The hydrothermal method of extracting sericin is more eco-friendly than are chemical and enzymatic methods. In this study, silk cocoons were cut into pieces and then subjected to hydrothermal extraction at three temperatures (160, 200, and 220 °C) to obtain sericin extracts (Sericin160, Sericin200, and Sericin220, respectively). Antioxidant activity and tyrosinase inhibition were measured to determine the extracts’ effectiveness. Sericin220 was the strongest antioxidant, with total phenol content, total flavonoid content, and ferric reducing power of 62.19 ± 0.04 mg gallic acid equivalents/g dry weight, 0.07 ± 0.01 mg quercetin equivalent/g dry weight, and 181.49 ± 0.024 mg vitamin C equivalent/g dry weight, respectively. The half-maximal inhibitory concentrations for DPPH and ABTS free-radical scavenging ability were 6.41 ± 0.05 and 0.79 ± 0.37 mg/mL, respectively. Sericin220 also exhibited the highest tyrosinase inhibition activity (70.82 ± 4.1 mg vitamin C equivalent/g), indicating its whitening potential.

The purpose of this study was to determine the antioxidant activity of the seed shells and kernels of Jatropha curcas L. The extracts obtained from five solutions (0%–95% ethanol) were tested and compared. Overall, the antioxidant capacity of seed shell extracts was higher than that of seed kernel extracts. The seed shell extract obtained using 95% ethanol exhibited the best antioxidant activity among the five solutions. The half-maximal inhibitory concentration (IC₅₀) of 1,1-diphenyl-2-picrylhydrazyl and free radical scavenging ability of 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) were 13.63 ± 0.15 and 6.75 ± 0.51 μg/mL, respectively. The reduction ability and total phenol content were 95.14 ± 27.04 μg ascorbic acid equivalents/mg of extract and 536.33 ± 8.62 μg gallic acid equivalents/mg of extract, respectively. In in vitro cytotoxicity assays, solutions with less than 250 μg/mL of seed shell extract had no major cytotoxicity. The seed shell of Jatropha curcas L. can be used as an antioxidant material and has potential for biomedical applications.

Androgen deprivation therapy (ADT) is one of the typical treatments used for patients with prostate cancer (PCa). ADT, however, may fail when PCa develops castration-resistance. Fatty acid synthase (FASN), a critical enzyme involved in fatty acid synthesis, is found to be upregulated in PCa. Since enzalutamide and ADT are frequently used for the treatment of PCa, this study aimed to unravel the underlying mechanism of combination of orlistat, a FASN inhibitor, and enzalutamide using PC3 cell line; and orlistat and castration in PC3 tumor-bearing animal model. Cytotoxicity was determined by AlamarBlue assay. Drug effects on the cell cycle and protein expressions were assayed by the flow cytometry and Western blot. Electromobility shift assay was used to evaluate the NF-κB activity. The tumor growth delay, expressions of the signaling–related proteins, and histopathology post treatments of orlistat and castration were evaluated in PC3 tumor-bearing mouse model. The results showed that orlistat arrested the PC3 cells at the G1 phase of the cell cycle and enhanced the cytotoxic effects of enzalutamide synergistically. Pretreatment with orlistat combined with castration inhibited the tumor growth significantly compared with those of castration and orlistat treatments alone in PC3 tumor-bearing mice. Combination treatment reduced both fatty acid synthase and NF-κB activities and their downstream effector proteins. The present study demonstrated the synergistic effects of orlistat combined with enzalutamide in vitro and castration in vivo on human prostate cancer.

Glioblastoma, the most common and aggressive brain tumor with low survival rate, is difficult to be cured by neurosurgery or radiotherapy. Mounting evidence has reported the anti-inflammatory and anticancer effects of curcumin on several types of cancer in preclinical studies and clinical trials. To our knowledge, there is no platform or system that could be used to effectively and real-timely evaluate the therapeutic efficacy of curcumin for glioblastoma multiforme (GBM). In this study, we constructed a lentivirus vector with triple-reporter genes (Fluc/GFP/tk) and transduced into rat F98 glioblastoma cells to establish an orthotopic F98/FGT glioma-bearing rat model. In the model, the therapeutic efficacies for curcumin alone, radiation alone, and their combination were evaluated via noninvasive bioluminescent imaging and overall survival measurements. At the cell level, curcumin is capable of causing a G2/M cell cycle arrest and sensitizing the F98 cells to radiation. In animal model, curcumin synergistically enhances the effects of radiotherapy on suppressing the growth of both transplanted glioma cells and in situ brain tumors, and extending the overall survival periods longer than those of curcumin alone and radiation alone treatments. In conclusion, we have demonstrated that curcumin may serve as a novel radiosensitizer to combine with radiotherapy using the triple-reporter F98/FGT animal model for effective and simultaneous evaluation of therapeutic efficacy.