Machine learning algorithms can be trained to estimate age from brain structural MRI. The difference between an individual’s predicted and chronological age, predicted age difference (PAD), is a phenotype of relevance to aging and brain disease. Here, we present a new deep learning approach to predict brain age from a T1-weighted MRI. The method was trained on a dataset of healthy Icelanders and tested on two datasets, IXI and UK Biobank, utilizing transfer learning to improve accuracy on new sites. A genome-wide association study (GWAS) of PAD in the UK Biobank data (discovery set: $$N=12378$$N=12378 , replication set: $$N=4456$$N=4456 ) yielded two sequence variants, rs1452628-T ( $$\beta =-0.08$$β=−0.08 , $$P=1.15\times{10}^{-9}$$P=1.15×10−9 ) and rs2435204-G ( $$\beta =0.102$$β=0.102 , $$P=9.73\times 1{0}^{-12}$$P=9.73×10−12 ). The former is nearKCNK2and correlates with reduced sulcal width, whereas the latter correlates with reduced white matter surface area and tags a well-known inversion at 17q21.31 (H2).

In this letter, we present a new method for the pansharpening of multispectral satellite imagery. Pansharpening is the process of synthesizing a high spatial resolution multispectral image from a low spatial resolution multispectral image and a high-resolution panchromatic (PAN) image. The method uses total variation to regularize an ill-posed problem dictated by a widely used explicit image formation model. This model is based on the assumptions that a linear combination of the bands of the pansharpened image gives the PAN image and that a decimation of the pansharpened image gives the original multispectral image. Experimental results are based on two real datasets and the quantitative quality of the pansharpened images is evaluated using a number of spatial and spectral metrics, some of which have been recently proposed and do not need a reference image. The proposed method compares favorably to other well-known methods for pansharpening and produces images of excellent spatial and spectral quality.

In this letter, we propose a method using a 3-D convolutional neural network to fuse together multispectral and hyperspectral (HS) images to obtain a high resolution HS image. Dimensionality reduction of the HS image is performed prior to fusion in order to significantly reduce the computational time and make the method more robust to noise. Experiments are performed on a data set simulated using a real HS image. The results obtained show that the proposed approach is very promising when compared with conventional methods. This is especially true when the HS image is corrupted by additive noise.

Blind hyperspectral unmixing is the process of expressing the measured spectrum of a pixel as a combination of a set of spectral signatures called endmembers and simultaneously determining their fractional abundances in the pixel. Most unmixing methods are strictly spectral and do not exploit the spatial structure of hyperspectral images (HSIs). In this article, we present a new spectral-spatial linear mixture model and an associated estimation method based on a convolutional neural network autoencoder unmixing (CNNAEU). The CNNAEU technique exploits the spatial and the spectral structure of HSIs both for endmember and abundance map estimation. As it works directly with patches of HSIs and does not use any pooling or upsampling layers, the spatial structure is preserved throughout and abundance maps are obtained as feature maps of a hidden convolutional layer. We compared the CNNAEU method to four conventional and three deep learning state-of-the-art unmixing methods using four real HSIs. Experimental results show that the proposed CNNAEU technique performs particularly well and consistently when it comes to endmembers' extraction and outperforms all the comparison methods.